8(<i>R</i>)-Hydroxyeicosapentaenoic acid (8<i>R</i>-HEPE) induces transcription of cholesterol efflux receptors via activation of liver X receptor in macrophages
8(<i>R</i>)-Hydroxyeicosapentaenoic acid (8<i>R</i>-HEPE) induces transcription of cholesterol efflux receptors via activation of liver X receptor in macrophages
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8(<i>R</i>)-羟基二十碳五烯酸 (8<i>R</i>-HEPE) 通过激活巨噬细胞中的肝脏 X 受体诱导胆固醇流出受体的转录
DOI：
10.1093/bbb/zbad025
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Miyasaka Raimu
中科院分区：
文献类型：
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作者：
Yamada Hidetoshi;Uemura Aiko;Miyasaka Raimu
血脂异常是动脉粥样硬化性心血管疾病发生的危险因素。从北太平洋磷虾（Euphausia pacifica）中提取的8-羟基二碳五烯酸（8-HEPE）可以降低LDL受体敲除小鼠的血浆低密度脂蛋白（LDL）胆固醇水平，并增加血浆高密度脂蛋白胆固醇水平。此外，8-HEPE还可以减少apoE敲除小鼠的动脉粥样硬化面积。在这项研究中，我们检测了8-HEPE在J774.1细胞中诱导胆固醇外排受体（abca1和abcg1）表达的立体化学特异性活性。我们的研究结果表明，8R-HEPE通过激活肝脏X受体诱导Abca1和Abcg1的表达，而8S-HEPE不引起这种活性。这些结果表明，从北太平洋磷虾中提取的8R-HEPE可能对血脂异常有有益作用。
Dyslipidemia is a risk factor for the development of atherosclerotic cardiovascular disease. 8-Hydroxyeicosapentaenoic acid (8-HEPE) from North Pacific krill (Euphausia pacifica) is known to reduce plasma low-density lipoprotein (LDL) cholesterol levels and increase plasma high-density lipoprotein cholesterol levels in LDL receptor knock-out mice fed a western diet. Moreover, 8-HEPE also reduces the area of aortic atherosclerosis in apoE knock-out mice fed the same diet. In this study, we examined the stereochemical-specific activity of 8-HEPE for inducing expression of cholesterol efflux receptors (Abca1andAbcg1) in J774.1 cells. Our findings show 8R-HEPE induces the expression of Abca1 and Abcg1 via activation of liver X receptor, whereas 8S-HEPE elicits no such activity. These results suggest that 8R-HEPE derived from North Pacific krill may have beneficial effects against dyslipidemia.