Dengue fever during pregnancy
Dengue fever during pregnancy
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DOI：
10.18999/nagims.80.2.241
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发表时间：
2018-05-01
影响因子：
0.9
通讯作者：
Kikkawa, Fumitaka
中科院分区：
文献类型：
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作者：
Trinh Tien Dat;Kotani, Tomomi;Kikkawa, Fumitaka
妊娠期间的登革热在东南亚是一个不断扩大的问题;然而，对母亲和新生儿的不良影响的了解仍然有限。因此，我们旨在确定登革热的影响。1月1日以来越南20例妊娠期登革热患者的临床信息。收集了2015年12月31日至2015年12月31日的数据，并回顾性调查了其结局。共有18名患者（90%）表现为非结构蛋白1阳性和原发感染。此外，4例患者（20%）早产，1例（5%）死产。所有活产新生儿均顺利出院。6例（30%）需要输注血小板，其中3例在分娩前输注，但无孕产妇死亡。此外，3例患者（15%）发生产后出血（PPH），其血小板浓度显著低于未发生PPH的患者[90.0（19.0 - 374.0）x 10（3）vs. 40.0（12.0 - 57.0）x 10（3）cell/mu，p = 0.001]。另外。PPH患者也表现为肝酶升高。血小板计数低的孕妇应被认为是PPH的高危人群。
Dengue fever during pregnancy is an expanding issue in Southeast Asia; however, the knowledge of adverse effects on mothers and neonates remains limited. Therefore, we aimed to determine the impact of dengue fever. The clinical information of 20 patients of dengue fever during pregnancy in Vietnam from January 1. 2015 to December 31, 2015 was collected and their outcomes were retrospectively investigated. A total of 18 patients (90%) presented with positivity of nonstructural protein 1, and a primary infection. Additionally, 4 patients (20%) had preterm deliveries and 1 (5%) had a stillborn child. Ail live-born neonates were discharged from the hospital uneventfully. Also, 6 patients (30%) required platelet transfusion and 3 of them received transfusion before delivery, but there were no maternal death. In addition, 3 cases of patients (15%) developed to postpartum hemorrhage (PPH), and their platelet concentrations were significantly lower than those of patients without PPH [90.0 (19.0 - 374.0) x 10(3) vs. 40.0 (12.0 - 57.0) x 10(3) cell/mu l, p = 0.001]. In addition. patients with PPH also presented with elevated liver enzymes. Pregnant patients with low platelet counts should he recognized as being at high risk for PPH.