Parallel Approaches for the Functionalization of Thietes: α-Metalation versus C-H Activation
Parallel Approaches for the Functionalization of Thietes: α-Metalation versus C-H Activation
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DOI：
10.1021/acs.orglett.8b01961
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发表时间：
2018-08-03
期刊：
影响因子：
5.2
通讯作者：
Didier, Dorian
中科院分区：
文献类型：
--
作者：
Eisold, Michael;Miiller-Deku, Adrian;Didier, Dorian
首次提出了通过两条互补的途径合成3，4-二取代噻托溴铵的方法。虽然第一种依赖于α-金属化，但第二种基于直接C-H官能化。描述了一个新的复杂的含硫四元环库，为新的生物活性类似物和小杂环的掺入铺平了道路。
For the first time, an approach to 3,4disubstituted thietes was developed through two complementary paths. While the first one relies on alpha-metalation, the second is based on direct C-H functionalization. A new library of sophisticated sulfur-containing four-membered rings is described, paving the way to new bioactive analogues and small heterocycle incorporation.