Association of Epstein-Barr virus with lymphoepithelioma-like carcinoma of the lung in southern China
Association of Epstein-Barr virus with lymphoepithelioma-like carcinoma of the lung in southern China
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DOI：
10.1309/148k-nd54-6njx-na61
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发表时间：
2000-08-01
影响因子：
3.5
通讯作者：
Zong, YS
中科院分区：
文献类型：
--
作者：
Han, AJ;Xiong, M;Zong, YS
为探讨肺内EB病毒(LELC)与EB病毒(EBV)感染的关系，应用原位杂交和免疫组织化学技术对32例LELC和19例非LELC肺癌组织中EBV编码的小分子非腺苷化RNA(EBER)、潜伏膜蛋白1(LMP1)和病毒衣壳抗原(VCA)进行了检测。32例中30例(94%)EBER阳性。30例EBER阳性肺LELC中，16例表达LMP1，7例表达VCA。与LELC相比，19例非LELC肺癌均未发现EBER-、LMP1-或VCA感染和肺LELC。EBV感染可能在肺LELC的肿瘤发生中起重要作用。除个别EBV进入溶血周期外，肺LELC以EBV潜伏感染为主。
To study the relationship between pulmonary LELC and Epstein-Barr virus (EBV) infection, we used in situ hybridization and immunohistochemistry techniques to detect the EBV-encoded small nonpolyadenylated RNA (EBER), latent membrane protein 1 (LMP1), and viral capsid antigen (VCA) in 32 cases of LELC and 19 cases of non-LELC lung carcinoma. Of the 32 cases, 30 (94%) showed EBER positivity. Of the 30 EBER-positive pulmonary LELC cases, 16 and 7 expressed LMP1 and VCA, respectively. In contrast with LELC, none of the 19 cases of a non-LELC lung carcinoma showed EBER-, LMP1-, or VCA infection and pulmonary LELC. EBV infection may have an essential role in the tumorigenesis of pulmonary LELC. EBV latent infection is the main status in pulmonary LELC except for individual EBV entering into a lytic cycle.