ENTRAINMENT OF CIRCADIAN-RHYTHMS - RETINOFUGAL PATHWAYS AND UNILATERAL SUPRACHIASMATIC NUCLEUS LESIONS
ENTRAINMENT OF CIRCADIAN-RHYTHMS - RETINOFUGAL PATHWAYS AND UNILATERAL SUPRACHIASMATIC NUCLEUS LESIONS
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DOI：
10.1016/0031-9384(82)90314-6
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发表时间：
1982-01-01
影响因子：
2.9
通讯作者：
STEPHAN, FK
中科院分区：
文献类型：
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作者：
DONALDSON, JA;STEPHAN, FK
本实验观察了视交叉上核（SCN）和腹外侧膝状体（LGN）的视交叉上核（SCN）传入在饮酒昼夜节律诱导中的作用。双侧病变的LGNv和初级视束没有影响的夹带饮酒节律的光暗周期，响应12小时相移的光暗周期，或在恒定的光或恒定的黑暗中的自由运行的昼夜节律的周期。单侧致盲或无LGNv病变的大鼠延迟了2天的相移率，并减少了持续光照下的自由运行节律。对于单侧SCN病变或此类病变合并同侧或对侧盲法的大鼠，再夹带率介于完整和单侧盲法大鼠之间;这表明单侧SCN病变部分逆转了单侧盲法的影响。单侧SCN病变对持续光照或黑暗中的自由运行节律的周期没有影响。单侧盲大鼠视网膜下丘脑束（RHT）对2SCN的不对称神经支配通过改变昼夜节律系统的相位响应曲线明显延迟了再夹带。这种变化可能是由两个SCN之间的神经连接介导的。
The role of retinohypothalamic input to the suprachiasmatic nuclei (SCN) as well as SCN afferents from the ventrolateral geniculate nuclei (LGN) in the entrainment of circadian drinking rhythms was investigated in the rat. Bilateral lesions of the LGNv and the primary optic tracts had no affect on the entrainment of drinking rhythms to a light-dark cycle, the response to a 12 h phase shift of the light-dark cycle, or on the period of the free-running circadian rhythm in constant light or constant darkness. Unilateral blinding in rats with or without LGNv lesions retarded the rate of phase shifting by 2 days and decreased the period of the free-running rhythm in constant light. For rats with unilateral SCN lesions, or such lesions combined with either ipsi- or contralateral blinding, the rate of re-entrainment was intermediate between intact and unilaterally blinded rats; this indicates that unilateral SCN lesions partially reversed the effects of unilateral blinding. Unilateral SCN lesions had no effect on the period of the free-running rhythm in constant light or darkness. The asymmetrical innervation of the 2 SCN by the [retinohypothalamic tract] (RHT) in unilaterally blinded rats apparently delays re-entrainment by changing the phase response curve of the circadian system. This change may be mediated by neural connections between the 2 SCN.