Prevalence of diabetes and ethnic differences in cardiovascular risk factors - The 1992 Singapore National Health Survey
Prevalence of diabetes and ethnic differences in cardiovascular risk factors - The 1992 Singapore National Health Survey
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DOI：
10.2337/diacare.22.2.241
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发表时间：
1999-02-01
期刊：
影响因子：
16.2
通讯作者：
Jacob, E
中科院分区：
文献类型：
--
作者：
Tan, CE;Emmanuel, SC;Jacob, E
目的-1992年新加坡全国健康调查的目的是确定目前的主要非传染性疾病及其危险因素的分布，包括糖尿病和血脂异常的患病率，在新加坡.研究设计和方法-不成比例的分层抽样和系统抽样相结合，用于选择调查的样本。最后的回应人数为3，568人，回应率为72.6%。受试者禁食10小时，并给予75克葡萄糖负荷，除了那些已知患有糖尿病。在葡萄糖负荷前和葡萄糖负荷后2 h采血。糖尿病的诊断是基于2小时葡萄糖单独。结果-糖尿病的年龄标准化患病率在新加坡居民年龄在18-69岁为8.4%，超过一半（58.5%）以前未确诊。糖尿病患病率在所有三个种族群体中都很高。糖耐量减低患病率为16.1%，高血压患病率为6.5%，经常吸烟者占19.0%。非糖尿病新加坡人的总胆固醇（平均值+/- SD）为5.18 +/- 1.02 mmol/l; 47.9%的胆固醇>5.2 mmol/l，而15.4%的胆固醇水平>6.3 mmol/l。平均低密度脂蛋白胆固醇为3.31 +/- 0.89 mmol/l;高密度脂蛋白胆固醇为1.30 +/- 0.32 mmol/l，甘油三酯为1.23 +/- 0.82 mmol/l。糖尿病、胰岛素抵抗、向心性肥胖、高血压、吸烟和血脂谱患病率的种族差异可以解释新加坡三个主要种族群体冠心病发病率的差异。
OBJECTIVE - The purpose of the 1992 Singapore National Health Survey was to determine the current distribution of major noncommunicable diseases and their risk factors, including the prevalence of diabetes and dyslipidemia, in Singapore.RESEARCH DESIGN AND METHODS - A combination of disproportionate stratified sampling and systematic sampling were used to select the sample for the survey. The final number of respondents was 3,568, giving a response rate of 72.6%. An subjects fasted for 10 h and were given a 75-g glucose load, except those known to have diabetes. Blood was taken before and 2 h after the glucose load. Diagnosis of diabetes was based on 2-h glucose alone.RESULTS - The age-standardized prevalence of diabetes in Singapore residents aged 18-69 years was 8.4%, with more than half (58.5%) previously undiagnosed. Prevalence of diabetes was high across all three ethnic groups. The prevalence of impaired glucose tolerance was 16.1%, that of hypertension was 6.5%, and 19.0% were regular smokers. The total cholesterol (mean +/- SD) of nondiabetic Singaporeans was 5.18 +/- 1.02 mmol/l; 47.9% had cholesterol >5.2 mmol/l, while 15.4% had levels >6.3 mmol/l. Mean LDL cholesterol was 3.31 +/- 0.89 mmol/l; HDL cholesterol was 1.30 +/- 0.32 mmol/l, and triglyceride was 1.23 +/- 0.82 mmol/l.CONCLUSIONS - Prevalence of diabetes was high across all three ethnic groups. Ethnic differences in prevalence of diabetes, insulin resistance, central obesity, hypertension, smoking, and lipid profile could explain the differential coronary heart disease rates in the three major ethnic groups in Singapore.