Characterization of the human CD5 endogenous retrovirus-E in B lymphocytes
Characterization of the human CD5 endogenous retrovirus-E in B lymphocytes
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DOI：
10.1038/sj.gene.6364253
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发表时间：
2005-12-01
影响因子：
5
通讯作者：
Youinou, P
中科院分区：
文献类型：
--
作者：
Renaudineau, Y;Vallet, S;Youinou, P
All T lymphocytes and some B lymphocytes express CD5. This coreceptor is encoded by one gene that consists of 11 exons. We have previously described a B cell-specific alternative exon 1, leading to the synthesis of a protein, devoid of leader peptide, and, therefore, retained in the cytoplasm. The novel exon 1 originates from a human endogenous retrovirus ( HERV) at a time interval between the divergence of New World monkeys from Old World monkeys, and prior to the divergence of humans from Old World monkeys. Based on sequence similarity to gamma-retroviruses, it was categorized as class I: based on the specificity of its primer binding site, it was allotted to the subclass E, and based on its location within the cd5 gene, named HERV-E. CD5. Alternative transcripts were detected in lymphoid organs including fetal liver ( not adult liver), more particularly in CD5-negative cell surface B-1b than in CD5-positive cell surface B-1a, and not at all in B-2 cells. By alignment of 5 0 long terminal repeats, HERV-E. CD5 was distinguished from similar proviruses. This could be central to the regulation of membrane expression of CD5 in human B lymphocytes, and, thereby, to the strength of the B-cell antigen receptor signaling.
