Association and interaction of APOA5, BUD13, CETP, LIPA and health-related behavior with metabolic syndrome in a Taiwanese population
Association and interaction of APOA5, BUD13, CETP, LIPA and health-related behavior with metabolic syndrome in a Taiwanese population
复制标题
DOI：
10.1038/srep36830
复制
发表时间：
2016-11-09
影响因子：
4.6
通讯作者：
Tsai, Shih-Jen
中科院分区：
文献类型：
--
作者：
Lin, Eugene;Kuo, Po-Hsiu;Tsai, Shih-Jen
罹患代谢综合征 (MetS) 的风险增加与 APOA5、APOC1、BRAP、BUD13、CETP、LIPA、LPL、PLCG1 和 ZPR1 基因相关。在这项复制研究中，我们重新评估了这些基因是否与台湾人群中的 MetS 及其各个组成部分独立地和/或通过复杂的相互作用相关。我们还分析了环境因素和这些基因之间的相互作用，影响 MetS 及其各个组成部分。这项研究总共评估了 3,000 名台湾受试者。测量了腰围、甘油三酯、高密度脂蛋白（HDL）胆固醇、收缩压和舒张压以及空腹血糖等代谢特征。我们的数据显示 MetS 与 APOA5 rs662799、BUD13 rs11216129、BUD13 rs623908、CETP rs820299 和 LIPA rs1412444 单核苷酸多态性 (SNP) 存在名义关联。此外，APOA5 rs662799、BUD13 rs11216129 和 BUD13 rs623908 与高甘油三酯、低 HDL、甘油三酯和 HDL 水平显着相关。此外，我们还发现 APOA5 rs662799、BUD13 rs11216129、BUD13 rs623908、CETP rs820299、LIPA rs1412444、饮酒、吸烟状况或体力活动对 MetS 及其各个组成部分的相互作用。我们的研究表明 APOA5、BUD13、CETP 和 LIPA 基因可能独立地以及通过基因-基因和基因-环境相互作用导致 MetS 风险。
Increased risk of developing metabolic syndrome (MetS) has been associated with the APOA5, APOC1, BRAP, BUD13, CETP, LIPA, LPL, PLCG1, and ZPR1 genes. In this replication study, we reassessed whether these genes are associated with MetS and its individual components independently and/or through complex interactions in a Taiwanese population. We also analyzed the interactions between environmental factors and these genes in influencing MetS and its individual components. A total of 3,000 Taiwanese subjects were assessed in this study. Metabolic traits such as waist circumference, triglyceride, high-density lipoprotein (HDL) cholesterol, systolic and diastolic blood pressure, and fasting glucose were measured. Our data showed a nominal association of MetS with the APOA5 rs662799, BUD13 rs11216129, BUD13 rs623908, CETP rs820299, and LIPA rs1412444 single nucleotide polymorphisms (SNPs). Moreover, APOA5 rs662799, BUD13 rs11216129, and BUD13 rs623908 were significantly associated with high triglyceride, low HDL, triglyceride, and HDL levels. Additionally, we found the interactions of APOA5 rs662799, BUD13 rs11216129, BUD13 rs623908, CETP rs820299, LIPA rs1412444, alcohol consumption, smoking status, or physical activity on MetS and its individual components. Our study indicates that the APOA5, BUD13, CETP, and LIPA genes may contribute to the risk of MetS independently as well as through gene-gene and gene-environment interactions.