Perceptions of parents on the participation of their infants in clinical research
Perceptions of parents on the participation of their infants in clinical research
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DOI：
10.1136/adc.2006.096073
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发表时间：
2006-12-01
影响因子：
5.2
通讯作者：
Bisgaard, H.
中科院分区：
文献类型：
--
作者：
Gammelgaard, A.;Knudsen, L. E.;Bisgaard, H.
目的：分析家长对婴幼儿参与综合性、侵入性临床研究的动机和认知。方法：对参与哥本哈根儿童哮喘前瞻性研究的23名婴幼儿哮喘母亲进行半结构化定性访谈。对访谈进行录音、转录并使用模板分析方法进行分析。结果：父母的动机是利他主义，以及让孩子定期接受医学专家检查以预防可能发生的哮喘的机会。家长们发现，让他们的孩子享受对研究诊所的访问非常重要，如果他们的孩子开始对这些访问产生负面反应，他们可以退出研究。有肺部或皮肤症状的儿童的父母与健康儿童的父母的态度没有明显差异。结论：以父母认为符合伦理的方式设计和完成针对婴幼儿的侵入性临床研究是可能的。
Objective: To analyse the motivations and perceptions of parents on the participation of their infants and young children in a comprehensive and invasive clinical research study.Methods: Semistructured qualitative interviews were conducted with 23 mothers with asthma whose infants and young children were participating in the Copenhagen Prospective Study on Asthma in Childhood. The interviews were audiotaped, transcribed and analysed using the template analysis method.Results: Parents were motivated by altruism and by the opportunity to get their child checked regularly by medical experts to prevent the possible development of asthma. Parents found it very important that their children enjoyed their visits to the research clinic, and that they could withdraw from the study if their child started responding negatively to those visits. No apparent difference was seen in the attitude between the parents of children with lung or skin symptoms and those of healthy children.Conclusions: It is possible to design and accomplish invasive clinical research on infants and young children in a manner that parents find ethically sound.