Molybdenum-based nanoclusters act as antioxidants and ameliorate acute kidney injury in mice
Molybdenum-based nanoclusters act as antioxidants and ameliorate acute kidney injury in mice
复制标题
钼基纳米簇作为抗氧化剂并改善小鼠急性肾损伤
DOI：
10.1038/s41467-018-07890-8
复制
发表时间：
2018-12-21
影响因子：
16.6
通讯作者：
Cai, Weibo
中科院分区：
文献类型：
--
作者：
Ni, Dalong;Jiang, Dawei;Cai, Weibo
急性肾损伤（阿基）是一种常见的活性氧（ROS）相关的肾脏疾病，每年导致许多死亡，但目前只有支持性治疗在诊所。高度期望开发在肾脏中具有高积累率的抗氧化剂以帮助预防阿基。在这里，我们报告了具有优先肾摄取的基于铯的聚氧乙烯酸盐（POM）纳米簇作为用于肾脏保护的新型纳米抗氧化剂。这些POM纳米团簇，具有容易变化的钼离子的价态，具有消除有害的ROS的能力。我们的研究结果表明，POM纳米团簇可以有效地减轻遭受阿基的小鼠的临床症状，如通过使用68 Ga-EDTA的动态PET成像、血清测试、肾组织染色和肾脏中的生物标志物检测所验证的。POM纳米团簇在活体动物中对阿基的保护作用表明探索其用于治疗阿基患者以及患有其他ROS相关疾病的患者的用途。
Acute kidney injury (AKI) is a common reactive oxygen species (ROS)-related renal disease that causes numerous deaths annually, yet only supportive treatment is currently available in the clinics. Development of antioxidants with high accumulation rates in kidneys is highly desired to help prevent AKI. Here we report molybdenum-based polyoxometalate (POM) nanoclusters with preferential renal uptake as novel nano-antioxidants for kidney protection. These POM nanoclusters, with a readily variable valence state of molybdenum ions, possess the capability to scavenge detrimental ROS. Our results demonstrate that POM nanoclusters can efficiently alleviate clinical symptoms in mice subjected to AKI, as verified by dynamic PET imaging with68Ga-EDTA, serum tests, kidney tissue staining, and biomarkers detection in the kidneys. The protective effect of POM nanoclusters against AKI in living animals suggests exploring their use for the treatment of AKI patients, as well as patients with other ROS-related diseases.