The tissue reactions of mice to infection with Heligmosmoides polygyrus.
The tissue reactions of mice to infection with Heligmosmoides polygyrus.
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小鼠对 Heligmosmoides polygyrus 感染的组织反应。
DOI：
10.1017/s0022149x0001124x
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发表时间：
1988
影响因子：
1.6
通讯作者：
Enriquez,FJ
中科院分区：
文献类型：
--
作者：
Cypess,RH;Lucia,HL;Dunsford,HA;Enriquez,FJ
对正常和抗性LAF小鼠的肠道进行组织学研究，以确定对多脑Heligmosomoides polygyrus再感染的抗性的时间和机制。在再感染期间，第三阶段的幼虫穿透肠壁的能力较弱。能够包囊的幼虫发育速度较慢，并引起包囊周围非特异性炎症的增加。从肠囊肿中出现后，前期成虫迅速消失，但从未观察到幼虫或成虫受伤或被破坏。将脱鞘的幼虫通过尾静脉注射到对照、致敏和耐药的BALB/c小鼠中。在第1、2、4和8天测量肺中截留幼虫周围的炎症反应。在致敏和耐药小鼠中均观察到炎症反应增强，主要由多形核细胞和一些圆形细胞组成，这些细胞在第2天达到峰值。在皮下接种脱鞘幼虫的两种AKR（非抗性）BALB/c（抗性）小鼠中也观察到类似的炎症反应增强。
The intestines of normal and resistant LAF mice were subjected to histologic study to determine the timing and mechanisms of resistance to reinfection by Heligmosomoides polygyrus. During reinfection third-stage larvae are less able to penetrate the intestinal wall.Larvae which are able to encyst develop at a slower rate and provoke an increase in nonspecific inflammation around their cysts. After emergence from intestinal cysts, preadults are rapidly lost, but at no time were injured or destroyed larvae or adults noted.Exsheathed larvae were injected via tail vein into control, sensitized and resistant BALB/c mice. The inflammatory response around entrapped larvae in the lung was measured at 1, 2, 4, and 8 days. A heightened inflammatory response, consisting primarily of polymorphonuclear cells with some round cells which peaked in size on day 2, was observed in both sensitized and resistant mice. A similar heightened inflammatory response was also observed in both AKR (non-resistant) BALB/c (resistant) mice vaccinated subcutaneously with exsheathed larvae.