B cells join T cell clusters in the host response to recurrent herpes simplex virus 2 infection.
B cells join T cell clusters in the host response to recurrent herpes simplex virus 2 infection.
复制标题
B 细胞与 T 细胞簇一起参与宿主对复发性单纯疱疹病毒 2 感染的反应。
DOI：
10.1172/jci148300
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发表时间：
2021
期刊：
影响因子：
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通讯作者：
Iwasaki,Akiko
中科院分区：
文献类型：
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作者：
Gehlhausen,JeffR;Iwasaki,Akiko
复发性生殖器疱疹皮损被各种白细胞浸润，但B细胞亚群在此过程中的作用尚不清楚。在本期JCI中，福特等人描述了单纯疱疹病毒2型（HSV-2）复发性病变中局部B细胞群的存在和抗体分泌作用。作者分析了HSV-2感染患者随时间推移和不同感染阶段的连续皮肤活检标本的综合阵列。使用免疫荧光和原位杂交，作者显示了罕见的IgD+幼稚B细胞和IgG表达抗体分泌细胞（ASC）的复发HSV-2病变包埋在CD 4 +T细胞丰富的真皮免疫浸润，其水平在病变再激活和愈合过程中短暂增加。值得注意的是，在复发性病变中检测到HSV-2特异性抗体的局部增加，而血清HSV-2抗体水平保持稳定。未来的研究需要了解这些访问组织的B细胞在疾病解决中的确切作用。
Recurrent genital herpes lesions are infiltrated by various leukocytes, yet the role of B cell subsets in this process is unknown. In this issue of theJCI, Ford et al. describe the presence and antibody-secreting role of local B cell populations in herpes simplex virus 2 (HSV-2) recurrent lesions. The authors analyzed a comprehensive array of sequential skin biopsy specimens from HSV-2–infected patients over time and at various stages of infection. Using immunofluorescence and in situ hybridization, the authors show the presence of rare IgD+naive B cells and IgG-expressing antibody-secreting cells (ASCs) in recurrent HSV-2 lesions embedded in CD4+T cell–rich dermal immune infiltrates, levels of which transiently increase during lesion reactivation and healing. Notably, local increases in HSV-2–specific antibodies in recurrent lesions were detected, whereas serum HSV-2 antibody levels remained stable. Future research is needed to understand the precise role of these tissue-visiting B cells in disease resolution.