Central diastolic pressure decay mediates the relationship between aortic stiffness and myocardial viability: potential implications for aortosclerosis-induced myocardial ischemia
Central diastolic pressure decay mediates the relationship between aortic stiffness and myocardial viability: potential implications for aortosclerosis-induced myocardial ischemia
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DOI：
10.1097/hjh.0000000000001436
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发表时间：
2017-10-01
影响因子：
4.9
通讯作者：
Ito, Sadayoshi
中科院分区：
文献类型：
--
作者：
Hashimoto, Junichiro;Ito, Sadayoshi
目的：主动脉硬化常发生于冠状动脉事件之前，但其病因机制尚不清楚。我们假设，心肌缺血的易感性可能是由于动脉硬化引起的改变，在中央血流动力学在calculole.Methods：使用无创性眼压和超声检查，我们调查了动脉压脉搏波波形，脉搏波速度（PWVs）和遵守222例高血压患者。舒张压衰减通过拟合单指数曲线定量为P（t）= P（0）e（-t）[：衰减指数; P-0：收缩末期压; t：收缩末期时间]。结果：主动脉压力衰减与桡动脉压力衰减呈指数关系（R-2= 0.98 ± 0.02），且主动脉压力衰减与桡动脉压力衰减的关系更为接近（P
Objective:Stiffening of the aorta often precedes coronary events, but little is known about the aetiological mechanism. We hypothesized that the predisposition to myocardial ischemia could be attributable to aortosclerosis-induced alterations in the central haemodynamics during diastole.Methods:Using noninvasive tonometry and ultrasonography, we investigated the arterial pressure pulse waveforms, pulse wave velocities (PWVs) and compliance in 222 patients with hypertension. The diastolic pressure decay was quantified by fitting a mono-exponential curve as P(t)= P(0)e(-t) [: decay index; P-0: end-systolic pressure; t: time from end-systole]. The myocardial oxygen supply/demand balance was estimated from the subendocardial viability index (SVI).Results:The aortic pressure decay fit to an exponential curve significantly (R-2=0.980.02) and more closely than the radial pressure decay (P