Initial demonstration of in vivo tracing of axonal projections in the macaque brain and comparison with the human brain using diffusion tensor Imaging and fast marching tractography
Initial demonstration of in vivo tracing of axonal projections in the macaque brain and comparison with the human brain using diffusion tensor Imaging and fast marching tractography
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DOI：
10.1006/nimg.2001.0994
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发表时间：
2002-04-01
期刊：
影响因子：
5.7
通讯作者：
Turner, R
中科院分区：
文献类型：
--
作者：
Parker, GJM;Stephan, KE;Turner, R
扩散张量成像（DTI）是一种磁共振成像技术，用于推断猕猴和人脑中的主要轴突投射。本研究探讨了使用已知的猕猴解剖连接作为评价DTI纤维束成像方法的“金标准”的可行性。使用快速行进纤维束成像（FMT），一种新的跟踪（纤维束成像）方法，从DTI数据中确定连接信息。我们表明，它是第一次，有可能确定，在一个完全非侵入性的方式，解剖连接路径和地图的解剖连接度量在猕猴大脑中使用标准的临床扫描仪，这些途径是一致的与已知的解剖。模拟人体解剖连接也提出了第一次使用FMT方法，并比较结果。目前的局限性的方法和进一步研究的可能性进行了讨论。(C)2002 Elsevier Science（美国）。
Diffusion tensor imaging (DTI), a magnetic resonance imaging technique, is used to infer major axonal projections in the macaque and human brain. This study investigates the feasibility of using known macaque anatomical connectivity as a "gold-standard" for the evaluation of DTI tractography methods. Connectivity information is determined from the DTI data using fast marching tractography (FMT), a novel tract-tracing (tractography) method. We show for the first time that it is possible to determine, in an entirely noninvasive manner, anatomical connection pathways and maps of an anatomical connectivity metric in the macaque brain using a standard clinical scanner and that these pathways are consistent with known anatomy. Analogous human anatomical connectivity is also presented for the first time using the FMT method, and the results are compared. The current limitations of the methodology and possibilities available for further studies are discussed. (C) 2002 Elsevier Science (USA).