Scleral Cautery with Iridectomy-An Experimental Study.
Scleral Cautery with Iridectomy-An Experimental Study.
复制标题
巩膜烧灼与虹膜切除术-实验研究。
DOI：
--
复制
发表时间：
1963
期刊：
影响因子：
--
通讯作者：
E. Regan
中科院分区：
文献类型：
--
作者：
E. Regan
1958年，SCHEIE描述了一种治疗青光眼的滤过手术，他称之为巩膜烧灼外周虹膜切除术。从那时起，我们越来越频繁地使用这种操作，我们对过滤发生的一致性印象深刻。因此，研究做过手术的猴子的眼睛似乎很有趣。众所周知，试图在实验动物的眼睛中产生滤过性气泡是不成功的。艾略特环钻术的介绍激发了人们对过滤瘢痕的产生和功能的兴趣。Kummell2于1913年对家兔进行了套管穿刺，发现到术后第10天，纤维结缔组织正在闭合手术缺损。Rochon-Duvigneaud和Ducamp3通过检查在穿刺后26天和32天取出的猫的眼睛得出结论，如果出现了瘘管，那是由于伤口边缘之间存在某种异质物质。1914年，Ellet(4)研究了兔眼的钻孔手术，他认为在一个病例中，结膜下囊肿表明可能有滤过，但clausen(5)和Holth6(6)都不能证明有滤过。Wilmer7（1927）指出，根据他的经验，在狗眼上钻孔有很大的愈合趋势，尽管几乎所有病例的显微镜检查都表明在眼压升高的情况下有可能有引流。1932年，Spaeth8研究了在兔子身上进行的虹膜包埋手术，得出结论：伤口内虹膜色素的存在促进了过滤。Spaeth观察到，手术后第13天，嵌套的虹膜和巩膜的连续切口表面之间形成了一层薄薄的空间。虹膜基质*来自哥伦比亚长老会医学中心眼科研究所和纽约市哥伦比亚大学内科和外科医学院眼科。这项研究得到了斯奈德眼科基金会的资助。
IN 1958 SCHEIE' described a filtering operation for glaucoma which he called peripheral iridectomy with scleral cauterv. Since that time we have employed this operation with increasing frequency and we have been impressed with the consistency with which filtration occurs. For this reason it seemed interesting to study the eyes of monkeys on which the operation had been performed. Attempts to produce filtering blebs in the eyes of experimental animals have been notoriously unsuccessful. The introduction of Elliot's trephination stimulated interest in the production and function of filtering cicatrices. Kummell2 in 1913 performed trephinations upon rabbits and found that by the tenth postoperative day fibrillary connective tissue was closing the surgical defect. From inspection of the cats' eyes removed twenty-six and thirty-two days after trephination, Rochon-Duvigneaud and Ducamp3 concluded that if fistulization occurred it was from the presence of some heterogeneous substance between the wound edges. In 1914 Ellet,4 studying the trephination operation on rabbit eyes, thought that in one instance a subconjunctival cyst indicated possible filtration, but neither Clausen5 nor Holth6 could demonstrate filtration, and Wilmer7 in 1927 stated that in his experience trephinings on dogs' eyes showed a great tendency to heal completely, although microscopic examination in nearly all cases indicated the possibility of drainage under conditions of increased intraocular pressure. In 1932, Spaeth8 studied iris inclusion operations performed on rabbits and concluded that the presence of iris pigment within the wound promoted filtration. Spaeth observed that by the thirteenth day after operation a thin space developed between the incarcerated iris and the contiguous cut surface of the sclera. The iris stroma then *From the Institute of Ophthalmology, Columbia-Presbyterian Medical Center and the Department of Ophthalmology, College of Physicians and Surgeons, Columbia University, New York City. This investigation was supported by a grant from the Snyder Ophthalmic Foundation.