Reconstruction of the human visual system based on DTI fiber tracking
Reconstruction of the human visual system based on DTI fiber tracking
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DOI：
10.1002/jmri.21098
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发表时间：
2007-10-01
影响因子：
4.4
通讯作者：
Kollias, Spyridon
中科院分区：
文献类型：
--
作者：
Staempfli, Philipp;Rienmueller, Anna;Kollias, Spyridon
目的：通过重建人类视觉通路，在体内应用和评估新开发的高级快速行进算法（aFM），其特征在于广泛的纤维交叉和分支区域，即，视交叉材料与方法：10例健康志愿者，采用磁共振弥散张量成像技术，对10例正常志愿者的外侧膝状体（LGN）进行磁共振弥散张量成像。由于邻近视交叉的骨性结构和充满空气的空间，应用高灵敏度编码（SENSE）降低因子以减少该区域的图像失真。为了重建视觉系统，分别选择三个不同的种子区域。结果：所有受试者的视觉系统重建结果均具有可重复性，重建的纤维通路与已知解剖结构吻合良好。结论：目前的工作表明，先进的aFM，这是专门设计用于克服广泛的纤维交叉区域内的跟踪限制，正确处理视交叉和LGN内的纤维交叉和分支，从而允许重建整个人类视觉纤维通路，从视神经的眶内段到视觉皮层。
Purpose: To apply and to evaluate the newly developed advanced fast marching algorithm (aFM) in vivo by reconstructing the human visual pathway, which is characterized by areas of extensive fiber crossing and branching, i.e., the optic chiasm. and the lateral geniculate nucleus (LGN).Materials and Methods: Diffusion tensor images were acquired in 10 healthy volunteers. Due to the proximity to bony structures and air-filled spaces of the optic chiasm, a high sensitivity encoding (SENSE) reduction factor was applied to reduce image distortions in this area. To reconstruct the visual system, three different seed areas were chosen separately. The results obtained by the aFM tracking algorithm were compared and validated with known anatomy.Results: The visual system could be reconstructed reproducibly in all subjects and the reconstructed fiber pathways are in good agreement with known anatomy.Conclusion: The present work shows that the advanced aFM, which is especially designed for overcoming tracking limitations within areas of extensive fiber crossing, handles the fiber crossing and branching within the optic chiasm and the LGN correctly, thus allowing the reconstruction of the entire human visual fiber pathway, from the intraorbital segment of the optic nerves to the visual cortex.