Training to criterion in eyeblink classical conditioning in Alzheimer's disease, Down's syndrome with Alzheimer's disease, and healthy elderly.
Training to criterion in eyeblink classical conditioning in Alzheimer's disease, Down's syndrome with Alzheimer's disease, and healthy elderly.
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对阿尔茨海默病、患有阿尔茨海默病的唐氏综合症以及健康老年人进行眨眼经典条件反射标准的培训。
DOI：
10.1037//0735-7044.110.1.22
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发表时间：
1996
影响因子：
1.9
通讯作者：
Papka,M
中科院分区：
文献类型：
--
作者：
Woodruff-Pak,DS;Romano,S;Papka,M
胆碱能拮抗剂东莨菪碱可延迟兔和人类眨眼经典条件反射（EBCC）的获得，但东莨菪碱处理的生物体最终获得条件反射（CR）。可能患有阿尔茨海默病（AD）的患者和患有唐氏综合征（DS/AD）的老年人已经破坏了胆碱能系统，并且EBCC表现非常差。假设可能患有AD和DS/AD的患者，如东莨菪碱注射微生物，如果给予足够的培训，将获得CR。12例可能的AD患者、12例DS/AD患者和6例健康老年对照个体参加了5次每日90次的EBCC试验。58%的可能AD，92%的DS-AD和100%的对照组参与者达到了学习标准。可能的AD、DS/AD和对照参与者在5次EBCC治疗中产生的CR百分比有统计学显著性增加。在可能的AD或DS/AD患者中，EBCC的神经底物没有消除，尽管学习机制被破坏。（PsycInfo数据库记录（c）2023阿帕，保留所有权利）
The cholinergic antagonist scopolamine delays acquisition of eyeblink classical conditioning (EBCC) in rabbits and humans, but scopolamine-treated organisms eventually acquire conditioned responses (CRs). Patients with probable Alzheimer's disease (AD) and older adults with Down's syndrome (DS/AD) have disrupted cholinergic systems and perform EBCC very poorly. It was hypothesized that patients with probable AD and DS/AD, like scopolamine-injected organisms, would acquire CRs if given sufficient training. Twelve probable AD patients, 12 DS/AD patients, and 6 healthy elderly control individuals participated in 5 daily 90-trial sessions of EBCC. Fifty-eight percent of the probable AD, 92% of the DS-AD, and 100% of the control participants achieved learning criterion. Probable AD, DS/AD, and control participants had statistically significant increases in the percentage of CRs produced over 5 EBCC sessions. The neural substrate for EBCC was not eliminated in probable AD or DS/AD patients, although the learning mechanism was disrupted.(PsycInfo Database Record (c) 2023 APA, all rights reserved)