Prognostic implication of silver-binding nucleolar organizer regions (AgNORs) in oral squamous cell carcinoma.
Prognostic implication of silver-binding nucleolar organizer regions (AgNORs) in oral squamous cell carcinoma.
复制标题
口腔鳞状细胞癌中银结合核仁组织区（AgNOR）的预后意义。
DOI：
10.1111/j.1600-0714.1991.tb00889.x
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Nobuo Tsuda
中科院分区：
文献类型：
--
作者：
Kazuo Sano;Hiroshi Takahashi;Shuichi Fujita;T. Inokuchi;M. B. Pe;H. Okabe;Nobuo Tsuda
银结合核仁组成区（AgNORs）计数切片福尔马林固定，石蜡包埋的口腔鳞状细胞癌组织块。对39例患者（预后不良组19例，预后良好组20例）进行了AgNOR计数与组织学分级的关系及AgNOR计数与预后的相关性研究。合并的平均AgNOR计数为：1级癌，6.39 +/- 1.67（平均值+/- SD; n = 35）; 2级，9.74 +/- 1.72（n = 3）。3级的平均AgNOR计数为6.19 +/- 2.37（n = 1）。预后不良组AgNOR计数高于预后良好组。AgNOR计数≥ 6.5者5年生存率明显低于AgNOR计数<6.5者。高AgNOR计数高度提示口腔鳞状细胞癌预后不良。
Silver-binding nucleolar organizer regions (AgNORs) were counted in sections from formalin-fixed, paraffin-embedded tissue blocks of oral squamous cell carcinoma. Thirty-nine cases, that comprised poor prognostic group (n = 19) and good prognostic group (n = 20), were examined with respect to the relation between AgNOR counts and histologic grading, and correlation between AgNOR counts and prognosis. The pooled mean AgNOR counts were: Grade 1 carcinomas, 6.39 +/- 1.67 (mean +/- SD; n = 35); Grade 2, 9.74 +/- 1.72 (n = 3). Mean AgNOR count of Grade 3 was 6.19 +/- 2.37 (n = 1). The pooled mean AgNOR count in poor prognostic group was higher than that in good prognostic group. Five-year survival rate of the cases with high AgNOR counts (greater than or equal to 6.5) was significantly lower than that with low AgNOR counts (less than 6.5). High AgNOR counts are highly suggestive of poor prognosis in oral squamous cell carcinoma.