Mechanisms shaping glutamate-mediated excitatory postsynaptic currents in the CNS
Mechanisms shaping glutamate-mediated excitatory postsynaptic currents in the CNS
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DOI：
10.1016/0959-4388(94)90098-1
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发表时间：
1994-01-01
影响因子：
5.7
通讯作者：
Spruston, Nelson
中科院分区：
文献类型：
--
作者：
Jonas, Peter;Spruston, Nelson
中枢神经系统神经元中的兴奋性突触后电流具有由AMPA/红藻氨酸盐型和NMDA型谷氨酸受体的共激活引起的双组分时程。在电生理学和分子生物学的新方法提供了一个更好的理解的因素，决定兴奋性突触后电流的动力学。最近的研究表明，突触间隙中神经递质浓度的时间过程，天然通道的门控特性，以及谷氨酸受体亚基的组成都似乎是重要的因素。
Excitatory postsynaptic currents in neurones of the central nervous system have a dual-component time course that results from the co-activation of AMPA/kainate-type and NMDA-type glutamate receptors. New approaches in electrophysiology and molecular biology have provided a better understanding of the factors that determine the kinectics of excitatory postsynaptic currents. Recent studies suggest that the time course of neurotransmitter concentration in the synaptic cleft, the gating properties of the native channels, and the glutamate receptor subunit composition all appear to be important factors.