Multisensory cortical signal increases and decreases during vestibular galvanic stimulation (fMRI)
Multisensory cortical signal increases and decreases during vestibular galvanic stimulation (fMRI)
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DOI：
10.1152/jn.2001.85.2.886
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发表时间：
2001-02-01
影响因子：
2.5
通讯作者：
Dieterich, M
中科院分区：
文献类型：
--
作者：
Bense, S;Stephan, T;Dieterich, M
对六名健康志愿者在前庭电（乳突）和皮肤电（颈部）刺激过程中的功能性磁共振成像血氧水平依赖性（BOLD）信号增加（激活）和 BOLD 信号减少（“失活”）进行比较，以区分前庭与眼部运动和伤害性功能。通过计算该组前庭激活减去皮肤激活的对比度，我们发现岛叶前部、丘脑旁正中和背外侧、壳核、顶下小叶 [布罗德曼区 (BA) 40]、中央前回（额眼区，BA 6）、额中回（前额皮质，BA 46/9）、颞中回的激活(BA 37)、颞上回 (BA 22) 和前扣带回 (BA 32) 以及两个小脑半球。这些激活可归因于多感觉前庭和眼部运动功能。此外，单受试者分析显示后岛叶明显不重叠激活，对应于猴子的顶岛前庭皮层。在前庭刺激期间，视觉皮层（BA 18、19）的信号也显着减少，而 BA 17 没有受到影响。在皮肤刺激期间发现了不同的“失活”；它包括颞中回和枕回的上顶枕区（BA 19/39/18）。在两种刺激条件下，体感皮层信号均减弱（BA 2/3/4）。刺激依赖性、抑制性前庭视觉和伤害性体感相互作用对于处理知觉和感觉运动控制可能具有重要的功能。
Functional magnetic resonance imaging blood-oxygenation-level-dependent (BOLD) signal increases (activations) and BOLD signal decreases ("deactivations") were compared in six healthy volunteers during galvanic vestibular (mastoid) and galvanic cutaneous (neck) stimulation in order to differentiate vestibular from ocular motor and nociceptive functions. By calculating the contrast for vestibular activation minus cutaneous activation for the group, we found activations in the anterior parts of the insula, the paramedian and dorsolateral thalamus, the putamen, the inferior parietal lobule [Brodmann area (BA) 40], the precentral gyrus (frontal eye field, BA 6), the middle frontal gyrus (prefrontal cortex, BA 46/9), the middle temporal gyrus (BA 37), the superior temporal gyrus (BA 22), and the anterior cingulate gyrus (BA 32) as well as in both cerebellar hemispheres. These activations can be attributed to multisensory vestibular and ocular motor functions. Single-subject analysis in addition showed distinctly nonoverlapping activations in the posterior insula, which corresponds to the parieto-insular vestibular cortex in the monkey. During vestibular stimulation, there was also a significant signal decrease in the visual cortex (BA 18, 19), which spared BA 17. A different "deactivation" was found during cutaneous stimulation; it included upper parieto-occipital areas in the middle temporal and occipital gyri (BA 19/39/18). Under both stimulation conditions, there were signal decreases in the somatosensory cortex (BA 2/3/4). Stimulus-dependent, inhibitory vestibular-visual, and nociceptive-somatosensory interactions may be functionally significant for processing perception and sensorimotor control.