Rates of asymptomatic respiratory virus infection across age groups
Rates of asymptomatic respiratory virus infection across age groups
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DOI：
10.1017/s0950268819000505
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发表时间：
2019-01-01
影响因子：
4.2
通讯作者：
Shaman, J.
中科院分区：
文献类型：
--
作者：
Galanti, M.;Birger, R.;Shaman, J.
呼吸道病毒感染是世界范围内疾病的主要原因。各种呼吸道病毒在人类中产生感染，其影响从无症状到危及生命不等。标准的监测系统通常只针对严重感染（急诊科门诊、住院、死亡），而不能追踪无症状或轻度感染。在这里，我们进行了一项跨多个年龄组的大规模社区研究，以评估18种呼吸道病毒的致病性。从2016年秋季到2018年春季，我们在纽约市的多个地点招募了214人，每周检测呼吸道病毒病原体，无论症状状态如何。我们将这些测试结果与参与者提供的感冒和流感症状的每日记录结合起来，并利用这些信息按病毒和年龄类别来描述症状的严重程度。大多数病毒的无症状感染率超过70%，但流感病毒和人偏肺病毒除外，这两种病毒产生的后果要严重得多。症状与感染频率呈负相关，儿童在各年龄组中得分最低。所有病毒的上呼吸道表现最为常见，而全身影响则不太典型。这些结果表明，无症状呼吸道病毒感染在普通人群中存在很高的负担。
Respiratory viral infections are a leading cause of disease worldwide. A variety of respiratory viruses produce infections in humans with effects ranging from asymptomatic to life- treathening. Standard surveillance systems typically only target severe infections ( ED outpatients, hospitalisations, deaths) and fail to track asymptomatic or mild infections. Here we performed a large- scale community study across multiple age groups to assess the pathogenicity of 18 respiratory viruses. We enrolled 214 individuals at multiple New York City locations and tested weekly for respiratory viral pathogens, irrespective of symptom status, from fall 2016 to spring 2018. We combined these test results with participant- provided daily records of cold and flu symptoms and used this information to characterise symptom severity by virus and age category. Asymptomatic infection rates exceeded 70% for most viruses, excepting influenza and human metapneumovirus, which produced significantly more severe outcomes. Symptoms were negatively associated with infection frequency, with children displaying the lowest score among age groups. Upper respiratory manifestations were most common for all viruses, whereas systemic effects were less typical. These findings indicate a high burden of asymptomatic respiratory virus infection exists in the general population.