Genetic variation at the interleukin-18 locus is associated with wheat-dependent exercise-induced anaphylaxis in the Han Chinese population
Genetic variation at the interleukin-18 locus is associated with wheat-dependent exercise-induced anaphylaxis in the Han Chinese population
复制标题
IL-18基因座的遗传变异与中国汉族人群中小麦依赖性运动引起的过敏反应有关
DOI：
10.1016/j.gene.2020.144462
复制
发表时间：
2020-05-05
期刊：
影响因子：
3.5
通讯作者：
Yin, Jia
中科院分区：
文献类型：
--
作者：
Gao, Xiang;Wen, Liping;Yin, Jia
目的：探讨白介素18(IL-18)基因单核苷酸多态性(SNPs)与中国汉族人群小麦依赖型运动性过敏反应(WDEIA)的关系。结果：经Bonferroni校正后，WDEIA组rs1946518的G等位基因频率显著高于对照组(P=0.0015)。Rs1946518的基因型分布在WDEIA组和对照组之间差异有统计学意义(P=0.0031)，GG纯合子与TT型相比具有更高的WDEIA危险性(P=0.05)。在rs1946518位，GT杂合子组的对数转化总IgE值显著高于TT基因型组(P=0.0024)。3个SNPs组成的单倍型AGG在WDEIA组中的出现频率显著高于对照组(P=0.003)。结论：Rs1946518上的G等位基因可能是WDEIA的一个危险标记。
Objective: To investigate the association of single nucleotide polymorphisms (SNPs) at the interleukin (IL)-18 locus with wheat-dependent exercise-induced anaphylaxis (WDEIA) in the Han Chinese population.Method: 130 patients with WDEIA and 600 healthy subjects were recruited for this study. Three tag SNPs (rs360729, rs360717 and rs1946518) were selected and genotyped, and total IgE and specific IgE levels were measured using the ImmunoCAP system.Results: After Bonferroni correction, the frequency of the G-allele in rs1946518 in the WDEIA group was significantly higher than that in control group (P = 0.0015). Genotypic distributions of rs1946518 significantly differed between WDEIA and control groups, and compared with the TT genotype, the homozygote GG genotype was associated with a higher risk of WDEIA (P = 0.0031). At position rs1946518, the log-transformed total IgE values were significantly higher in the group with the heterozygous GT genotype than in TT genotype group (P = 0.0024). Haplotype AGG formed by three SNPs alleles occurred significantly more frequently in WDEIA group than in control group (P = 0.003).Conclusion: The minor allele G at position rs1946518 might serve as a marker for the risk of WDEIA.