Pathogenesis of Chagas heart disease: role of autoimmunity
Pathogenesis of Chagas heart disease: role of autoimmunity
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DOI：
10.1016/s0001-706x(01)00202-9
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发表时间：
2002-02-01
期刊：
影响因子：
2.7
通讯作者：
Leon, JS
中科院分区：
文献类型：
--
作者：
Engman, DM;Leon, JS
查加斯心脏病是由原生动物寄生虫克氏锥虫感染引起的。大多数死于这种疾病的人的心脏明显没有寄生虫，这使得一些人提出了疾病发病机制的自身免疫基础。这一假设已经非常难以测试，因为其他机制的组织炎症可能共存于设置活动性感染，在这里，我们审查了拟议的机制查加斯病发病机制，并提出新的证据，支持在这些其他机制的背景下，自身免疫性心脏炎症的贡献。虽然我们对自身免疫问题还没有一个明确的答案，但我们希望我们的观点将为参与辩论的人提供关于这一具有挑战性的问题的新视角。(C)2002 Elsevier Science B.V.保留所有权利。
Chagas heart disease is caused by infection with the protozoan parasite Trypanosoma cruzi. The apparent absence of parasites from the hearts of most individuals who succumb to this illness has led some to propose an autoimmune basis for disease pathogenesis. This hypothesis has been extremely difficult to test, because other mechanisms of tissue inflammation may coexist in the setting of active infection, Here we review the proposed mechanisms of Chagas disease pathogenesis and present new evidence in support of an autoimmune contribution to cardiac inflammation in the context of these other mechanisms. While we do not yet have a definitive answer to the autoimmunity question, we hope that our views will provide those engaged in the debate fresh perspective on this challenging issue. (C) 2002 Elsevier Science B.V. All rights reserved.