C-REACTIVE PROTEIN AND MARKERS FOR THROMBOPHILIA IN PATIENTS WITH CHRONIC PLAQUE PSORIASIS
C-REACTIVE PROTEIN AND MARKERS FOR THROMBOPHILIA IN PATIENTS WITH CHRONIC PLAQUE PSORIASIS
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DOI：
10.1177/039463201002300423
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发表时间：
2010-10-01
影响因子：
3.5
通讯作者：
Girolomoni, G.
中科院分区：
文献类型：
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作者：
Gisondi, P.;Malerba, M.;Girolomoni, G.
慢性斑块状银屑病与心血管事件风险增加相关。本研究的目的是检测银屑病患者获得性和遗传性血栓形成倾向的常见标志物。对172例银屑病患者和198名对照者进行了横断面研究。测定血浆凝固蛋白C、凝固蛋白S、同型半胱氨酸、叶酸、C反应蛋白（CRP）、纤维蛋白原、活化蛋白C抵抗和抗凝血酶III活性。银屑病患者CRP和同型半胱氨酸水平高于对照组（5.9 ± 7.1 vs 3.1 ± 2.4 mg/L，p=0.0003和16.3 ± 12.8 vs 10.4 ± 4.6 umol/L，p=0.0001;平均值+/- SD），而银屑病患者的叶酸水平低于对照组（4.3 +/- 7.2 vs 12.6 +/- 7.9 p=0.006）。凝血蛋白C、凝血蛋白S、纤维蛋白原、活化蛋白C抵抗、抗凝血酶III活性在病例组和对照组均在正常范围内。在多变量回归分析中，银屑病严重程度是高CRP的独立预测因子。结论：银屑病患者血清CRP和同型半胱氨酸水平升高，且与病情严重程度相关。这些数据表明，银屑病患者中观察到的血栓性心血管事件的风险增加应归因于获得性而不是遗传性血栓状态。
Chronic plaque psoriasis is associated to an increased risk of cardiovascular events. The aim of our study is to test patients with psoriasis for common markers of acquired and inherited thrombophilia. A cross-sectional study on 172 patients with psoriasis and 198 controls was carried out. The plasma levels of coagulation protein C, coagulation protein S, homocysteine, folic acid, C-reactive protein (CRP) and fibrinogen as well as activated protein C resistance and antithrombin III activity, were measured. CRP and homocysteine levels were higher in patients with psoriasis than in controls (5.9 +/- 7.1 vs 3.1 +/- 2.4 mg/L, p=0.0003 and 16.3 +/- 12.8 vs 10.4 +/- 4.6 umol/L, p=0.0001; mean +/- SD) whereas folic acid was lower in psoriatic patients compared to controls (4.3 +/- 7.2 vs 12.6 +/- 7.9 p=0.006). Levels of coagulation protein C, coagulation protein S, fibrinogen as well as activated protein C resistance, antithrombin III activity were within normal ranges both in cases and controls. In a multivariate regression analysis, psoriasis severity was an independent predictor of higher CRP. In conclusion, high levels of serum CRP and homocysteine were found in patients with psoriasis, related to the severity of the disease. These data suggest that the increased risk of thrombotic cardiovascular events observed in psoriasis patients should be ascribed to an acquired rather than inherited thrombophilic status.