CtIP, a multivalent adaptor connecting transcriptional regulation, checkpoint control and tumor suppression
CtIP, a multivalent adaptor connecting transcriptional regulation, checkpoint control and tumor suppression
复制标题
DOI：
10.4161/cc.5.15.3127
复制
发表时间：
2006-08-01
期刊：
影响因子：
4.3
通讯作者：
Lee, Wen-Hwa
中科院分区：
文献类型：
--
作者：
Wu, Guikai;Lee, Wen-Hwa
CtIP最初被表征为转录辅阻遏物CtBP的相互作用蛋白。除了转录调控外，CtIP在DNA损伤反应和细胞周期检查点控制中起重要作用。最近的证据表明，在G（1）/S转换过程中，CtIP的病毒因子样S期促进活性抵消Rb抑制，以促进E2 F-指导的反式激活。在小鼠中的遗传研究揭示了CtIP在抑制与寿命缩短相关的肿瘤发生方面的单倍体不足。因此，CtIP作为连接细胞周期检查点控制、转录调节和肿瘤抑制的多价衔接子出现。
CtIP was originally characterized as an interacting protein for the transcriptional corepressor CtBP. In addition to transcriptional regulation, CtIP plays an important role in the DNA damage response and cell cycle checkpoint control. Recent evidence points to a viral factor-like S phase promoting activity of CtIP in counteracting Rb repression to facilitate E2F-directed transactivation during the G(1)/S transition. Genetic studies in mice revealed the haploid insufficiency of CtIP in suppressing tumorigenesis associated with shortened life span. Thus, CtIP emerges as a multivalent adaptor that connects cell cycle checkpoint control, transcriptional regulation and tumor suppression.