INCREASES IN BONE-DENSITY DURING TREATMENT OF MEN WITH IDIOPATHIC HYPOGONADOTROPIC HYPOGONADISM
INCREASES IN BONE-DENSITY DURING TREATMENT OF MEN WITH IDIOPATHIC HYPOGONADOTROPIC HYPOGONADISM
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DOI：
10.1210/jcem-69-4-776
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发表时间：
1989-10-01
影响因子：
5.8
通讯作者：
CROWLEY, WF
中科院分区：
文献类型：
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作者：
FINKELSTEIN, JS;KLIBANSKI, A;CROWLEY, WF
为了评估性腺激素替代对严重性腺功能减退导致的骨质疏松症患者骨密度的影响，我们用125I光子吸收仪测量了桡骨远端皮质骨密度，用定量计算机断层扫描测量了21例孤立GnRH缺乏症男性的腰椎小梁骨密度，同时将血清睾酮水平维持在正常成年男性范围12-31个月（平均+-）。硒，23.7 +-。1.1)。在最初有骨骺融合的男性中（n = 15），皮质骨密度从0.71 +-增加。0.02 ~ 0.74 .+。0.01 g/cm2 (P < 0.01)，而骨小梁骨密度无明显变化（P < 0.01）。9与119相比。7毫克/立方厘米)。在最初骨骺开放的男性中（n = 6），皮质骨密度从0.62 +-增加。0.01 ~ 0.70 .+-。0.03 g/om2 (P < 0.01)，而骨小梁骨密度从96。13到109。12 mg/cm3 （P < 0.01）。皮质骨密度增加0.03 .+-。骨骺融合者为0.01 g/cm2，骨骺融合者为0.08 g/cm2。骨骺开放者0.02 g/cm2 （P < 0.05）。尽管有这些增加，但皮质骨密度和骨小梁骨密度都没有恢复到正常水平。髂骨活检的组织形态学分析表明，大多数男性患有低周转率骨质疏松症，尽管一些男性患有正常到高周转率骨质疏松症。我们的结论是，gnrh缺乏的男性，特别是骨骼发育不成熟的男性，在激素替代期间骨密度增加。
To assess the effects of gonadal steroid replacement on bone density in men with osteoporosis due to severe hypogonadism, we measured cortical bone density in the distal radius by 125I photon absorptiometry and trabecular bone density in the lumbar spine by quantitative computed tomography in 21 men with isolated GnRH deficiency while serum testosterone levels were maintained in the normal adult male range for 12-31 months (mean .+-. SE, 23.7 .+-. 1.1). In men who initially had fused epiphyses (n = 15), cortical bone density increased from 0.71 .+-. 0.02 to 0.74 .+-. 0.01 g/cm2 (P < 0.01), while trabecular bone density did not change (116 .+-. 9 compared with 119 .+-. 7 mg/cm3). In men who initially had open epiphyses (n = 6), cortical bone density increased from 0.62 .+-. 0.01 to 0.70 .+-. 0.03 g/om2 (P < 0.01), while trabecular bone density increased from 96 .+-. 13 to 109 .+-. 12 mg/cm3 (P < 0.01). Cortical bone density increased 0.03 .+-. 0.01 g/cm2 in men with fused epiphyses and 0.08 .+-. 0.02 g/cm2 in men with open epiphyses (P < 0.05). Despite these increases, neither cortical nor trabecular bone density returned to normal levels. Histomorphometric analyses of iliac crest bone biopsies demonstrated that most of the men had low turnover osteoporosis, although some men had normal to high turnover osteoporosis. We conclude that bone density increases during gonadal steroid replacement of GnRH-deficient men, particularly in men who are skeletally immature.