Non-criteria antiphospholipid antibodies in antiphospholipid syndrome: Diagnostic value added.
Non-criteria antiphospholipid antibodies in antiphospholipid syndrome: Diagnostic value added.
复制标题
抗磷脂综合征中的非标准抗磷脂抗体：增加诊断价值。
DOI：
10.3389/fimmu.2022.972012
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发表时间：
2022
影响因子：
7.3
通讯作者：
中科院分区：
文献类型：
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作者：
非标准抗磷脂抗体(APL)提高了抗磷脂综合征(APS)的诊断价值，有助于更好地识别血清阴性APS(SNAP)。然而，非标准急性早幼粒细胞白血病的临床应用和诊断价值并不一致。本研究旨在调查7种非标准急性早幼粒细胞白血病在APS队列中的患病率和临床意义。对175例APS患者、122例其他自身免疫性疾病患者和50例健康对照进行了抗磷脂酰丝氨酸/凝血酶原(APS/PT)抗体、抗磷脂酰乙醇胺抗体(APE)、抗Annexin V抗体(AAnnexinV)、抗磷脂酰丝氨酸抗体(APS)、抗磷脂酰丝氨酸/凝血酶原抗体(APS)、抗磷脂混合抗体(APhL)、抗磷脂酰乙醇胺抗体(APE)、抗Annexin V抗体(AAnnexinV)、抗磷脂酰丝氨酸抗体(APS)、抗磷脂混合抗体(APhL)、APhL IgM的检测。在本研究中，非标准APL的发生率最高的是AnnexinV(58.86%)。APhL-Ig G和APS-Ig M诊断APS的特异度最高(95.35%)，APS/PT的Youden指数最高(0.3991)。AAnnexinV在SNAP中的感染率最高(43.3%)，其次是APhL IgM(21.7%)、APE(16.7%)和APS/PT(16.7%)。APhL-Ig G、APS/PT和APS-Ig G与血栓事件呈正相关[APhL-Ig G：优势比(OR)=2.26，95%可信区间(CI)1.18~4.34，p=0.013；Ap s/PT：OR=2.48，95%CI：1.32~4.69，p=0.004；APS Ig G：OR=1.9，95%CI1.01~3.6 0，p=0.046]。纳入非标准APL后，APS诊断的准确率从65.7%提高到87.4%。我们的数据提供了证据，证明加入非标准的APL可以提高APS的诊断准确性。APhL-Ig G、APS/PT和APS-Ig G可能是预测APS血栓形成风险的潜在生物标志物。
Non-criteria antiphospholipid antibodies (aPLs) increase the diagnostic value for antiphospholipid syndrome (APS) and contribute to better recognition of seronegative APS (SNAPS). However, the clinical utility and the diagnostic value of non-criteria aPLs are inconsistent. This study aimed to investigate the prevalence and clinical significance of 7 non-criteria aPLs in a large APS cohort. Seven non-criteria aPLs, including anti-phosphatidylserine/prothrombin (aPS/PT) antibodies IgG/IgA/IgM, anti-phosphatidylethanolamine antibodies (aPE) IgG/IgA/IgM, anti-Annexin V antibodies (aAnnexinV) IgG/IgA/IgM, anti-phosphatidylserine antibodies (aPS) IgM, aPS IgG, antibodies directed against a mixture of phospholipids (APhL) IgG, and APhL IgM were tested among 175 patients with APS, 122 patients with other autoimmune diseases (as disease controls), and 50 healthy controls. In the present study, the highest prevalence of non-criteria aPLs was seen in aAnnexinV (58.86%). APhL IgG and aPS IgM showed the highest specificity (95.35%) and aPS/PT showed the highest Youden index (0.3991) for the diagnostic value of APS. The aAnnexinV also showed the highest prevalence in SNAPS (43.3%), followed by APhL IgM (21.7%), aPE (16.7%) and aPS/PT (16.7%). APhL IgG, aPS/PT, and aPS IgG showed positive association with thrombotic events in APS patients [APhL IgG: odds ratio (OR) = 2.26, 95% confidence interval (CI) 1.18-4.34, p = 0.013; aPS/PT: OR = 2.48, 95% CI: 1.32-4.69, p = 0.004; aPS IgG: OR = 1.90, 95% CI 1.01-3.60, p = 0.046; respectively). The inclusion of the non-criteria aPLs increased the accuracy of APS diagnosis from 65.7% to 87.4%. Our data provide evidence that adding the non-criteria aPLs can improve the diagnostic accuracy in APS. APhL IgG, aPS/PT, and aPS IgG may be potential biomarkers to predict the risk of thrombosis in APS.
影响因子：
4.9
作者：
da Rosa GP;Sousa-Pinto B;Ferreira E;Araújo O;Barilaro G;Bettencourt P;Cervera R;Espinosa G
通讯作者：
Espinosa G