Comparison of antimicrobial susceptibility between invasive and non-invasive Shigella organisms
Comparison of antimicrobial susceptibility between invasive and non-invasive Shigella organisms
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DOI：
10.1016/s0924-8579(02)00270-4
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发表时间：
2003-03-01
影响因子：
10.8
通讯作者：
Iwanaga, M
中科院分区：
文献类型：
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作者：
Honma, Y;Sasakawa, C;Iwanaga, M
对10株志贺氏菌进行了药敏试验，比较了每株志贺氏菌的侵袭性（含侵袭质粒）和非侵袭性。根据对侵袭性志贺氏菌和非侵袭性志贺氏菌的最小抑制浓度（MIC）差异，将抗菌药物的活性分为三类。对于1型，侵入性和非侵入性生物的MIC （MIC间隙）之间没有差异。对于2型，一个菌株的入侵生物的MIC高于该菌株的非入侵生物的MIC。在第三种类型中，志贺氏菌通过III型分泌器吸收大环内酯类，比非侵入性生物更有效地抑制侵入性生物的生长。(C) 2002 Elsevier Science B.V.与International Society of Chemotherapy。版权所有。
Antimicrobial susceptibility was determined for ten strains of Shigella spp. comparing invasive (invasion plasmid containing) and non-invasive members of each strain. The activity of the antimicrobial agents could be classified into three types from the differences between the minimum inhibitory concentration (MIC) for the invasive and non-invasive shigellae. For type 1, there was no difference between the MIC (an MIC gap) for invasive and non-invasive organisms. For type 2, the MIC for the invasive organisms of a strain was higher than that of non-invasive organisms of the strain. In the third type, macrolides taken in by shigellae through the type III secretion apparatus, more effectively inhibited the growth of invasive than non-invasive organisms. (C) 2002 Elsevier Science B.V. and the International Society of Chemotherapy. All rights reserved.