Biomarkers-A General Review.
Biomarkers-A General Review.
复制标题
DOI：
10.1002/cpph.19
复制
发表时间：
2017-03-17
影响因子：
--
通讯作者：
Ferner, Robin E
中科院分区：
文献类型：
--
作者：
Aronson, Jeffrey K;Ferner, Robin E
生物标记物是一种生物学观察，它替代并理想地预测更难观察的临床相关终点或中间结果。使用临床生物标记物比直接测量最终临床终点更容易和更便宜，而且生物标记物通常在较短的时间跨度内测量。它们可用于疾病筛查、诊断、表征和监测；作为预后指标；用于开发个体化治疗干预措施；用于预测和治疗药物不良反应；用于识别细胞类型；以及用于药效学和剂量反应研究。为了了解生物标记物的价值，有必要了解生物标记物和相关临床终点之间的病理生理学关系。好的生物标志物应该是可测量的，几乎没有变异性，应该有相当大的信噪比，并且应该迅速和可靠地响应条件或其治疗的变化。©2017 John Wiley&Sons，Inc.
A biomarker is a biological observation that substitutes for and ideally predicts a clinically relevant endpoint or intermediate outcome that is more difficult to observe. The use of clinical biomarkers is easier and less expensive than direct measurement of the final clinical endpoint, and biomarkers are usually measured over a shorter time span. They can be used in disease screening, diagnosis, characterization, and monitoring; as prognostic indicators; for developing individualized therapeutic interventions; for predicting and treating adverse drug reactions; for identifying cell types; and for pharmacodynamic and dose-response studies. To understand the value of a biomarker, it is necessary to know the pathophysiological relationship between the biomarker and the relevant clinical endpoint. Good biomarkers should be measurable with little or no variability, should have a sizeable signal to noise ratio, and should change promptly and reliably in response to changes in the condition or its therapy. © 2017 by John Wiley & Sons, Inc.