Efficient Photodynamic Therapy of Prostate Cancer Cells through an Improved Targeting of the Cation-Independent Mannose 6-Phosphate Receptor
Efficient Photodynamic Therapy of Prostate Cancer Cells through an Improved Targeting of the Cation-Independent Mannose 6-Phosphate Receptor
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DOI：
10.3390/ijms20112809
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发表时间：
2019-06-01
影响因子：
5.6
通讯作者：
Morere, Alain
中科院分区：
文献类型：
--
作者：
Bouffard, Elise;Jimenez, Chiara Mauriello;Morere, Alain
本研究的目的是开发高效靶向分子，以特异性作用于为前列腺癌光动力疗法（PDT）设计的介孔二氧化硅纳米粒子（MSNs）。我们选择的策略是开发一种新型化合物，以提高对前列腺癌中过表达的不依赖阳离子的甘露糖 - 6 - 磷酸受体的靶向性。这种原始糖类，一种接枝在用于PDT的MSN表面的二甘露糖苷 - 羧酸盐（M6C - Man），导致更高的内吞作用，从而提高了MSNs的功效。
The aim of the present work is the development of highly efficient targeting molecules to specifically address mesoporous silica nanoparticles (MSNs) designed for the photodynamic therapy (PDT) of prostate cancer. We chose the strategy to develop a novel compound that allows the improvement of the targeting of the cation-independent mannose 6-phosphate receptor, which is overexpressed in prostate cancer. This original sugar, a dimannoside-carboxylate (M6C-Man) grafted on the surface of MSN for PDT applications, leads to a higher endocytosis and thus increases the efficacy of MSNs.