Contrast-enhanced digital mammography: Initial clinical experience
Contrast-enhanced digital mammography: Initial clinical experience
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DOI：
10.1148/radiol.2283020961
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发表时间：
2003-09-01
期刊：
影响因子：
19.7
通讯作者：
Plewes, DB
中科院分区：
文献类型：
--
作者：
Jong, RA;Yaffe, MJ;Plewes, DB
目的：探讨静脉注射造影剂配合全视野数字化乳房摄影检查对乳腺病变的诊断价值。材料与方法：对22例因怀疑乳腺影像异常而行乳腺活检的妇女进行对比增强数字化乳房摄影检查。在获得第一次和第二次图像之间，通过静脉注射造影剂，获得了6个受影响乳房的连续图像。图像处理包括配准和对数减法。评估病变的存在、形态和增强动力学。病变类型、大小和病理结果与对比增强数字乳腺摄影结果相关。结果：在对比增强数字乳腺摄影中，在10例经活检证实的癌症患者中，有8例观察到强化。1例导管原位癌和1例浸润性导管癌均未见强化。在12例首次诊断为恶性但良性病变的病例中，有7例未见强化。形态与病理诊断大体一致。病变增强的动力学与增强磁共振成像相似，但并不一致。结论：本初步研究结果提示，增强数字乳腺摄影可能有助于在乳腺摄影致密的乳腺中识别病变。对比度增强的数字乳房X光检查作为乳腺癌的诊断工具的进一步研究是有必要的。
PURPOSE: To investigate the potential of using intravenous contrast material with full-field digital mammography to facilitate the detection and characterization of lesions in the breast.MATERIALS AND METHODS: Twenty-two women scheduled for biopsy because they were suspected of having abnormalities at breast imaging underwent imaging with contrast material-enhanced digital mammography. Six sequential images of the affected breast were obtained, with a contrast agent injected intravenously between the time the first and second images were obtained. Image processing included registration and logarithmic subtraction. Lesions were evaluated for the presence, morphology, and kinetics of enhancement. Lesion type, size, and pathologic findings were correlated with the findings at contrast-enhanced digital mammography.RESULTS: At contrast-enhanced digital mammography, enhancement was observed in eight of 10 patients with biopsy-proved cancers. In one case of ductal carcinoma in situ and one case of invasive ductal carcinoma, enhancement was not observed. No enhancement was seen in seven of 12 cases in which lesions were suspected of being malignant at initial imaging but were benign. Morphology generally correlated with the pathologic diagnosis. The kinetics of lesion enhancement showed similarity to that seen with gadolinium-enhanced magnetic resonance imaging but was not consistent.CONCLUSION: The results of this preliminary study suggest that contrast-enhanced digital mammography potentially may be useful in identification of lesions in the mammographically dense breast. Further investigation of contrast-enhanced digital mammography as a diagnostic tool for breast cancer is warranted.