Soft drinks, fructose consumption, and the risk of gout in men: prospective cohort study
Soft drinks, fructose consumption, and the risk of gout in men: prospective cohort study
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DOI：
10.1136/bmj.39449.819271.be
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发表时间：
2008-02-09
影响因子：
105.7
通讯作者：
Curhan, Gary
中科院分区：
文献类型：
--
作者：
Choi, Hyon K.;Curhan, Gary
目的探讨含糖软饮料和果糖摄入量与男性痛风发病风险的关系。前瞻性队列超过12年。设置卫生专业人员随访研究。参与者46,393名在基线时没有痛风病史的男性通过有效的食物频率问卷提供了软饮料和果糖摄入量的信息。主要结果测量：符合美国风湿病学会痛风调查标准的痛风事件。结果在12年的随访中，报告了755例确诊的痛风事件。增加含糖软饮料的摄入量与痛风的风险增加有关。与每月饮用少于一份含糖软饮料的人相比，每周饮用5-6份的人患痛风的多变量相对风险为1.29(95%可信区间1.00至1.68)，每天饮用一份的人患痛风的多变量相对风险为1.45(1.02至2.08)，每天饮用两份或两份以上的人患痛风的多变量相对风险为1.85（1.08至3.16；趋势P =0.002）。无糖软饮料与痛风风险无关（趋势P =0.99）。随着果糖摄入量的增加，痛风的多变量相对危险度分别为1.00、1.29、1.41、1.84和2.02 （1.49 ~ 2.75；P为趋势值）
Objective To examine the relation between intake of sugar sweetened soft drinks and fructose and the risk of incident gout in men.Design Prospective cohort over 12 years.Setting Health professionals follow-up study.Participants 46 393 men with no history of gout at baseline who provided information on intake of soft drinks and fructose through validated food frequency questionnaires.Main outcome measure Incident cases of gout meeting the American College of Rheumatology survey criteria for gout.Results During the 12 years of follow-up 755 confirmed incident cases of gout were reported. Increasing intake of sugar sweetened soft drinks was associated with an increasing risk of gout. Compared with consumption of less than one serving of sugar sweetened soft drinks a month the multivariate relative risk of gout for 5-6 servings a week was 1.29 (95% confidence interval 1.00 to 1.68), for one serving a day was 1.45 (1.02 to 2.08), and for two or more servings a day was 1.85 (1.08 to 3.16; P for trend=0.002). Diet soft drinks were not associated with risk of gout (P for trend=0.99). The multivariate relative risk of gout according to increasing fifths of fructose intake were 1.00, 1.29, 1.41, 1.84, and 2.02 (1.49 to 2.75; P for trend