Effects of Chemical Composition and Microstructure in Human Milk and Infant Formulas on Lipid Digestion
Effects of Chemical Composition and Microstructure in Human Milk and Infant Formulas on Lipid Digestion
复制标题
母乳和婴儿配方奶粉中的化学成分和微观结构对脂质消化的影响。
DOI：
10.1021/acs.jafc.0c00745
复制
发表时间：
2020
影响因子：
6.1
通讯作者：
Xiong Hua
中科院分区：
文献类型：
--
作者：
Yuan Tinglan;Zhu Xuemei;Mu Guangqing;Qlan Fang;Xiong Hua
婴儿配方奶粉（IF）是母乳（HM）不可用时婴儿的重要替代品;然而，经常观察到其“脂肪不足”并且显示不同的代谢表型，这可能影响婴儿的生长和大脑发育。考虑到乳脂消化率可能影响脂肪的吸收和代谢，进而影响代谢表型，因此研究IF和HM的脂肪消化行为具有重要价值。在本研究中，我们研究了HM的体外脂肪消化特性，并与四种配方（IF 1，2，3，4）进行了比较，包括富含OPO脂质的IFs（IF 1和IF 3）和含有常见混合植物油的IFs（IF 2和IF 4）。结果显示，HM的最终脂质水解程度（98.9 ± 2.70%）高于IF 1和IF 3（分别为90.4 ± 3.39和91.1 ± 1.67%）（p< 0.05）和IF 2和IF 4（分别为81.9 ± 1.64和79.9 ± 1.05%）（p< 0.01）。在HM胃消化结束时观察到天然脂肪球和蛋白质聚集，并且在肠消化中聚集体变得更小，然后在60 - 120 min内分解，而在IF中观察到大量聚集体，这可能减缓脂质消化。人乳和IFs在脂肪消化方面的吸收差异需要进一步研究，以阐明营养与婴儿发育和生长的相关性。
Infant formula (IF) is an important substitute for infants when human milk (HM) is unavailable; however, it was often observed with “insufficient fat” and showed different metabolic phenotypes, which may affect the growth and brain development of the infant. Considering that the milk fat digestion rate may affect the fat absorption and metabolism and further influence the metabolic phenotype, it is valuable to study the fat digestive behaviors of IF and HM. In the current study, we investigated thein vitrofat digestive properties of HM in comparison to four formulas (IF1, 2, 3, 4) including IFs enriched in OPO lipids (IF1 and IF3) and IFs with common mixed plant oils (IF2 and IF4). Results showed that the extent of eventual lipid hydrolysis of HM (98.9 ± 2.70%) was higher than those of IF1 and IF3 (90.4 ± 3.39 and 91.1 ± 1.67%, respectively) (p< 0.05) and IF2 and IF4 (81.9 ± 1.64 and 79.9 ± 1.05% respectively) (p< 0.01). Native fat globules and protein aggregation were observed at the end of HM gastric digestion, and the aggregates became smaller and then resolved from 60 to 120 min in intestinal digestion, while a large number of aggregates were observed in IF, which may slow the lipid digestion. The absorption differences between HM and IFs in lipid digestion need further study to elucidate the nutritional relevance to infant development and growth.