Spatial Point Process Analysis of Promyelocytic Leukemia Nuclear Bodies
Spatial Point Process Analysis of Promyelocytic Leukemia Nuclear Bodies
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DOI：
10.1007/978-90-481-9899-3_2
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发表时间：
2011-01-01
期刊：
影响因子：
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通讯作者：
Stephens, David A.
中科院分区：
文献类型：
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作者：
Umande, Philip P.;Stephens, David A.
由于核体 (NB) 早幼粒细胞白血病 (PML) 与多种人类疾病有关，包括早幼粒细胞白血病和艾滋病 (-)，人们对核体 (NB) 早幼粒细胞白血病 (PML) 产生了广泛的兴趣。PML NB 与其周围以及其他 NB（如 RNA 聚合酶 II (RNA Pol II)）相互作用的概念非常重要，因为它可以提高我们对 PML 功能的理解。本文采用空间点处理方法进行多变量分析，以评估 PML NB 相对于 RNA Pol II 的空间位置之间的关系。我们还提出了一个模型。对于 PML NB 位置。通过将模型与 PML NB 结合起来，我们能够深入了解 PML NB 相对于其自身和核边界如何在细胞核中分布。
There has been widespread interest in the nuclear body (NB) Promyelocytic leukemia (PML) because of its link to several human disorders, including Promyelocytic leukemia and AIDS(-) The notion of PML NB interaction with its surrounding and other NBs such as RNA Polymerase II (RNA Pol II) is of great importance as it can improve our understanding of the function of PML. In this paper, spatial point process methods are used to conduct multivariate analysis to assess the relationship between the spatial locations of PML NBs relative to RNA Pol II. We also propose a model. for PML NB locations. By luting a Model to the PML NBs we are able to gain insight into how PML NBs are distributed across the nucleus in relation to themselves and the nuclear boundary.