CD80 Regulates Th17 Cell Differentiation in Coxsackie Virus B3-Induced Acute Myocarditis
CD80 Regulates Th17 Cell Differentiation in Coxsackie Virus B3-Induced Acute Myocarditis
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CD80 调节柯萨奇病毒 B3 诱导的急性心肌炎中 Th17 细胞的分化
DOI：
10.1007/s10753-017-0681-7
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发表时间：
2018-02-01
期刊：
影响因子：
5.1
通讯作者：
Gao, Xingcui
中科院分区：
文献类型：
--
作者：
Huang, Yanlan;Li, Yong;Gao, Xingcui
摘要分化簇蛋白复合物CD 80/CD 86调节自身免疫性疾病中Th 1/Th 2分化。为探讨CD 80/CD 86对急性病毒性心肌炎（VMC）时Th 17细胞分化的影响，我们用科萨基病毒B3（CVB 3）感染C57 BL/6小鼠，观察抗CD 80/CD 86单克隆抗体（mAb）对VMC时Th 17细胞分化的影响。进一步观察抗CD 80/CD 86单克隆抗体对Th 17细胞分化的影响。抗CD 80单抗可明显抑制Th 17细胞分化和ROR-γt mRNA表达，而抗CD 86单抗在体内和体外均无作用。我们的发现，CD 80调节Th 17分化支持抗CD 80 mAb作为急性VMC有效的新免疫靶点的潜在效用。
AbstractThe cluster of differentiation protein complex, CD80/CD86, regulates Th1/Th2 differentiation in autoimmune disease. In order to establish the effects of CD80/CD86 on Th17 cell differentiation in acute viral myocarditis (VMC), we infected C57BL/6 mice with Coxsackie virus B3 (CVB3) and examined the effects of the treatment with anti-CD80/CD86 monoclonal antibodies (mAbs) on Th17 cell differentiationin vivo. The effects of anti-CD80/CD86 mAbs on Th17 cell differentiation were further evaluatedin vitro. The treatment with anti-CD80 mAb induced marked suppression of Th17 cell differentiation and ROR-γt mRNA expression, whereas anti-CD86 mAb alone had no effect, bothin vivoandin vitro. Our finding that CD80 regulates Th17 differentiation supports the potential utility of anti-CD80 mAb as an effective new immunotherapeutic target in acute VMC.