Effect of micropatterning induced surface hydrophobicity on drug release from electrospun cellulose acetate nanofibers
Effect of micropatterning induced surface hydrophobicity on drug release from electrospun cellulose acetate nanofibers
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DOI：
10.1016/j.apsusc.2017.07.197
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发表时间：
2017-12-31
影响因子：
6.7
通讯作者：
Eichhorn, Stephen J.
中科院分区：
文献类型：
--
作者：
Adepu, Shivakalyani;Gaydhane, Mrunalini K.;Eichhorn, Stephen J.
双氯芬酸钠等低半衰期药物的持续释放和防止突然释放对于预防药物相关毒性至关重要。静电纺丝纳米纤维最近已成为控制和持续药物释放的潜在载体材料。在这里，我们提出了一种简便的方法，通过载药电纺醋酸纤维素（CA）纳米纤维的模板辅助微图案化来调节表面润湿性，以防止突然释放。首先将已知量的药物（双氯芬酸钠）与 CA 混合，然后以纳米织物的形式进行静电纺丝。这种初纺网络本质上是亲水性的。然而，当通过非导电模板（即具有 50 和 100 μm 尺寸开口的尼龙网）进行静电纺丝时，产生了两种疏水性微图案 CA 纳米织物。对我们的纳米纤维垫进行了体外透皮测试；这些测试表明，制造用于透皮药物释放的贴剂是可能的。此外，我们的结果表明，通过优化的微图案尺寸，与非图案样品相比，透皮系统可以实现长达 12 小时的零级持续药物释放。这种图案导致疏水表面的表面润湿性发生变化，从而导致亲水药物的受控扩散。图案化有助于控制初始爆发释放，这是一个重要的发现，特别是对于低半衰期药物。 (C) 2017 Elsevier B.V. 保留所有权利。
Sustained release and prevention of burst release for low half-life drugs like Diclofenac sodium is crucial to prevent drug related toxicity. Electrospun nanofibers have emerged recently as potential carrier materials for controlled and sustained drug release. Here, we present a facile method to prevent burst release by tuning the surface wettability through template assisted micropatterning of drug loaded electrospun cellulose acetate (CA) nanofibers. A known amount of drug (Diclofenac sodium) was first mixed with CA and then electrospun in the form of a nanofabric. This as-spun network was hydrophilic in nature. However, when electrospinning was carried out through non-conducting templates, viz nylon meshes with 50 and 100 mu m size openings, two kinds of hydrophobic micro-patterned CA nanofabrics were produced. In vitro transdermal testing of our nanofibrous mats was carried out; these tests were able to show that it would be possible to create a patch for transdermal drug release. Further, our results show that with optimized micro-patterned dimensions, a zero order sustained drug release of up to 12 h may be achieved for the transdermal system when compared to non-patterned samples. This patterning caused a change in the surface wettability, to a hydrophobic surface, resulting in a controlled diffusion of the hydrophilic drug. Patterning assisted in controlling the initial burst release, which is a significant finding especially for low half-life drugs. (C) 2017 Elsevier B.V. All rights reserved.