Peripheral nerve conduits: technology update.
Peripheral nerve conduits: technology update.
复制标题
DOI：
10.2147/mder.s59124
复制
发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Hasirci V
中科院分区：
文献类型：
--
作者：
Arslantunali D;Dursun T;Yucel D;Hasirci N;Hasirci V
周围神经损伤是一个世界性的临床问题，它可导致中枢神经系统(CNS)与周围器官之间沿感觉和运动神经的神经元通讯中断，并影响患者的生活质量。治疗完全性损伤的主要要求是无张力、端到端的修复。当无法进行端到端修复时，可使用周围神经移植物或神经导管。自体移植的可获得性有限，以及同种和异种移植的缺点，如免疫反应，迫使研究人员研究和开发替代方法，主要是神经导管。在这篇综述中，介绍了各种类型的导管材料(由生物和合成聚合物制成)和设计(管状、纤维和基质类型)的最新信息。
Peripheral nerve injury is a worldwide clinical problem which could lead to loss of neuronal communication along sensory and motor nerves between the central nervous system (CNS) and the peripheral organs and impairs the quality of life of a patient. The primary requirement for the treatment of complete lesions is a tension-free, end-to-end repair. When end-to-end repair is not possible, peripheral nerve grafts or nerve conduits are used. The limited availability of autografts, and drawbacks of the allografts and xenografts like immunological reactions, forced the researchers to investigate and develop alternative approaches, mainly nerve conduits. In this review, recent information on the various types of conduit materials (made of biological and synthetic polymers) and designs (tubular, fibrous, and matrix type) are being presented.