Influenza vaccine strain selection and recent studies on the global migration of seasonal influenza viruses
Influenza vaccine strain selection and recent studies on the global migration of seasonal influenza viruses
复制标题
DOI：
10.1016/j.vaccine.2008.07.078
复制
发表时间：
2008-09-12
期刊：
影响因子：
5.5
通讯作者：
Smith, Derek J.
中科院分区：
文献类型：
--
作者：
Russell, Colin A.;Jones, Terry C.;Smith, Derek J.
人类的年度流感流行影响5-15%的人口，估计每年在全世界造成50万人死亡[Stohr K.流感-世卫组织关心。Lancet Infectious Diseases 2002;2（9）：517]。这种病毒可以年复一年地感染这一比例的人，因为这种病毒具有广泛的进化能力，从而逃避免疫反应。例如，自从1968年甲型流感（H3 N2）亚型进入人类群体以来，流感疫苗的A（H3 N2）组分不得不更新近30次，以跟踪病毒的演变并保持有效。世界卫生组织全球流感监测网络（WHO GISN）跟踪和分析流感病毒的演变和流行病学，主要目的是选择疫苗株，并通过旨在更好地了解病毒演变和流行病学的研究改进毒株选择过程。在这里，我们给出了一个概述的菌株选择过程，并概述了最近的调查季节性流感病毒的全球迁移。(c)2008年由Elsevier Ltd.出版
Annual influenza epidemics in humans affect 5-15% of the population, causing an estimated half million deaths worldwide per year [Stohr K. Influenza-WHO cares. Lancet Infectious Diseases 2002;2(9):517]. The virus can infect this proportion of people year after year because the virus has an extensive capacity to evolve and thus evade the immune response. For example, since the influenza A(H3N2) subtype entered the human population in 1968 the A(H3N2) component of the influenza vaccine has had to be updated almost 30 times to track the evolution of the viruses and remain effective. The World Health Organization Global Influenza Surveillance Network (WHO GISN) tracks and analyzes the evolution and epidemiology of influenza viruses for the primary purpose of vaccine strain selection and to improve the strain selection process through studies aimed at better understanding virus evolution and epidemiology. Here we give an overview of the strain selection process and outline recent investigations into the global migration of seasonal influenza viruses. (c) 2008 Published by Elsevier Ltd.