NEURONS GENERATED IN THE ADULT BRAIN ARE RECRUITED INTO FUNCTIONAL CIRCUITS
NEURONS GENERATED IN THE ADULT BRAIN ARE RECRUITED INTO FUNCTIONAL CIRCUITS
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DOI：
10.1126/science.6474166
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发表时间：
1984-01-01
期刊：
影响因子：
56.9
通讯作者：
NOTTEBOHM, F
中科院分区：
文献类型：
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作者：
PATON, JA;NOTTEBOHM, F
成年金丝雀（Serinus canarius）接受了 3H 标记的胸苷注射，这是 DNA 合成的标记。最后一次注射后三十天，记录尾部上纹状体腹侧核神经元的细胞内电位，该核是端脑的发声控制核；然后将辣根过氧化物酶注射到这些相同的细胞中。在回收的 74 个用辣根过氧化物酶标记的神经元中，其中 7 个的细胞核被放射性标记。这 7 个神经元中有 4 个对听觉刺激做出了反应。这些双标记神经元显然是在 3H 标记胸苷治疗期间或之后（成年期间）产生的，随后并入功能性神经回路。
Adult canaries, Serinus canarius, received injections of 3H-labeled thymidine, a marker of DNA synthesis. Thirty days after the last injection, intracellular potentials were recorded from neurons in the nucleus hyperstriatum ventralis pars caudalis, a vocal control nucleus in the telencephalon; these same cells were then injected with horseradish peroxidase. Of the 74 neurons labeled with horseradish peroxidase that were recovered, the nuclei of 7 were radioactively labeled. Four of these 7 neurons had responded to auditory stimuli. These double-labeled neurons were apparently generated during or after the 3H-labeled thymidine treatment (during adulthood) and subsequently incorporated into functional neural circuits.