Test-retest reliability of freesurfer measurements within and between sites: Effects of visual approval process.
Test-retest reliability of freesurfer measurements within and between sites: Effects of visual approval process.
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DOI：
10.1002/hbm.22856
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发表时间：
2015-09
影响因子：
4.8
通讯作者：
DeLorenzo C
中科院分区：
文献类型：
--
作者：
Iscan Z;Jin TB;Kendrick A;Szeglin B;Lu H;Trivedi M;Fava M;McGrath PJ;Weissman M;Kurian BT;Adams P;Weyandt S;Toups M;Carmody T;McInnis M;Cusin C;Cooper C;Oquendo MA;Parsey RV;DeLorenzo C
在过去的十年中，许多研究已经使用自动化过程来分析磁共振成像（MRI）数据，例如皮质厚度，这是神经元健康的一个指标。由于图像处理软件（例如，FreeSurfer），标准做法是依靠自动化结果，而不对中间处理进行目视检查。在这项工作中，40名健康对照者的结构MRI扫描两次，用于确定四组受试者中FreeSurfer衍生皮质测量的重测可靠性-25名通过目视检查（批准）的受试者，15名未通过目视检查（不批准）的受试者，一个组合组，以及10名受试者（Travel）的子集，其测试和重测扫描发生在不同的地点。用重测相关、组内相关系数和差异百分比来衡量Destrieux和Desikan-Killiany（DK）量表的信度。在批准的受试者中，皮质厚度/表面积/体积（仅DK atlas）的可靠性为：TRC（0.82/0.88/0.88）、ICC（0.81/0.87/0.88）、PD（0.86/1.19/1.39），当纳入未批准的受试者时，这代表了这些指标的显著改善。旅行受试者的结果表明，皮质厚度的可靠性比皮质表面积和体积更敏感的网站差异。为了确定目视检查对MRI衍生皮质厚度研究所需样本量的影响，计算了显示组间差异所需的受试者数量。在成像研究中心之间、目视检查批准/不批准的受试者之间以及不同尺寸的区域之间观察到的显著差异表明，应谨慎使用这些指标。
In the last decade, many studies have used automated processes to analyze magnetic resonance imaging (MRI) data such as cortical thickness, which is one indicator of neuronal health. Due to the convenience of image processing software (e.g., FreeSurfer), standard practice is to rely on automated results without performing visual inspection of intermediate processing. In this work, structural MRIs of 40 healthy controls who were scanned twice were used to determine the test–retest reliability of FreeSurfer-derived cortical measures in four groups of subjects—those 25 that passed visual inspection (approved), those 15 that failed visual inspection (disapproved), a combined group, and a subset of 10 subjects (Travel) whose test and retest scans occurred at different sites. Test–retest correlation (TRC), intraclass correlation coefficient (ICC), and percent difference (PD) were used to measure the reliability in the Destrieux and Desikan–Killiany (DK) atlases. In the approved subjects, reliability of cortical thickness/surface area/volume (DK atlas only) were: TRC (0.82/0.88/0.88), ICC (0.81/0.87/0.88), PD (0.86/1.19/1.39), which represent a significant improvement over these measures when disapproved subjects are included. Travel subjects’ results show that cortical thickness reliability is more sensitive to site differences than the cortical surface area and volume. To determine the effect of visual inspection on sample size required for studies of MRI-derived cortical thickness, the number of subjects required to show group differences was calculated. Significant differences observed across imaging sites, between visually approved/disapproved subjects, and across regions with different sizes suggest that these measures should be used with caution.