Effect of atrial natriuretic hormone on hypertonic saline-induced suppression of the renin-aldosterone system.
Effect of atrial natriuretic hormone on hypertonic saline-induced suppression of the renin-aldosterone system.
复制标题
心房钠尿激素对高渗盐水诱导的肾素-醛固酮系统抑制的影响。
DOI：
10.1093/ajh/7.6.543
复制
发表时间：
1994
影响因子：
3.2
通讯作者：
Shenker,Y
中科院分区：
文献类型：
--
作者：
Wazna,J;Burge,M;Meranda,D;Shenker,Y
为了评估生理剂量的心房钠尿激素 (ANH) 对高渗盐水诱导的肾素醛固酮系统抑制的影响，对 9 名健康受试者进行了 3 次研究： 1) 低盐 (LS) 饮食并输注 2 小时安慰剂； 2) 在LS上输注人SerTyr28ANH (0.6 pmol/kg/min)2小时(LS + ANH)； 3) 采用高盐 (HS) 饮食并输注 2 小时安慰剂。在每个研究日输注的第二个小时内，受试者还接受 3% 盐水 (0.1 mL/kg/min) 输注。由于一名受试者的抽样误差，使用八名受试者的数据进行分析。在 ANH 输注期间，血浆 ANH 水平增加约两倍，并达到与 HS 的 ANH 水平相似的水平。在所有研究日输注 3% 盐水期间，血清钠增加 3-4 mEq/L，血清渗透压增加 7-8 mOsm/L。 ANH 水平在 3% 盐水输注期间保持稳定。在 ANH 输注的第一个小时内，血浆肾素活性 (PRA) 下降约 24%，醛固酮水平下降约 27%。高渗盐水导致 PRA 和醛固酮进一步抑制。每种条件下的抑制程度相似，高渗盐水输注结束时的水平达到盐水输注开始时水平的约60%。我们的结论是，低剂量 ANH 输注似乎对 PRA 和醛固酮对高渗盐水的反应没有任何重大影响。美国高血压杂志 1994；7：543-549
To evaluate the effect of physiologic doses of atrial natriuretic hormone (ANH) on hypertonic salineinduced renin-aldosterone system suppression, nine healthy subjects were studied three times: 1) on a low-salt (LS) diet with a 2 h placebo infusion; 2) on LS with 2 h infusion of human SerTyr28ANH (0.6 pmol/kg/min)(LS + ANH); and 3) on a high-salt (HS) diet with a 2 h placebo infusion. On each study day during the second hour of infusion, subjects also received 3% saline (0.1 mL/ kg/min) infusion. Data from eight subjects were used for analysis because of a sampling error in one subject. During ANH infusion, plasma ANH levels increased about twofold and reached levels similar to ANH levels on HS. Serum sodium increased by 3-4 mEq/L, and serum osmolality increased by 7-8 mOsm/L during 3% saline infusion on all study days. ANH levels remained stable during 3% saline infusion. During the first hour of ANH infusion, plasma renin activity (PRA) decreased by about 24% and aldosterone levels by about 27%. Hypertonic saline caused further suppression of PRA and aldosterone. The extent of the suppression was similar under each condition, and the levels at the end of hypertonic saline infusion reached about 60% of the levels at the beginning of the saline infusion. We conclude that low-dose ANH infusion does not seem to have any major influence on PRA and aldosterone response to hypertonic saline. Am J Hypertens 1994;7:543-549