Efficacy of a one-shot marbofloxacin treatment on acute pleuropneumonia after experimental aerosol inoculation of nursery pigs
Efficacy of a one-shot marbofloxacin treatment on acute pleuropneumonia after experimental aerosol inoculation of nursery pigs
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DOI：
10.1186/s40813-018-0089-2
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发表时间：
2018-06-22
影响因子：
3.4
通讯作者：
Waldmann, Karl-Heinz
中科院分区：
文献类型：
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作者：
Hoeltig, Doris;Rohde, Judith;Waldmann, Karl-Heinz
背景：猪胸膜肺炎是由猪胸膜肺炎放线杆菌引起的一种细菌性呼吸道疾病。该病的急性暴发往往伴随着高死亡率和经济损失。由于重症患者经常需要对动物进行抗生素治疗，在实验条件下，比较了单次大剂量马博沙星和三次恩诺沙星的疗效。方法：采用盲法、对照、随机和阻断剂量确认研究，以验证单次给药8 mg/kg马博沙星(160 mg/ml)、Forcyl(R)猪、维多酚SA、法国)用于治疗实验性猪胸膜肺炎弧菌2型气雾剂接种后的急性猪胸膜肺炎。结果与2.5 mg/kg恩诺沙星连续三天治疗和模拟(生理盐水)治疗进行了比较。疗效评价标准为治疗后肺部病变严重程度、细菌学治愈情况和临床病程。结果：36头育成猪随机分为3组：马博沙星组(T1)、恩诺沙星组(T2)和假手术组(T3)。在所有疗效标准中，马博沙星和恩诺沙星与模拟治疗组相比有统计学上的显著优势(p<；0.05)。两个治疗组(T1：1头猪；T2：0头猪；T3：8头猪)因症状严重而需要挽救安乐死的情况显著减少。治疗开始后第6天，10只(T1)、10只(T2)仔猪临床治愈，而T3只有1只仔猪临床痊愈。两组患者的肺损伤程度(肺损伤评分平均值T1：3.9，T2：6.0，T3：21.1)和肺组织细菌分离(治疗开始后第6天：T1=0头猪；T2=1头猪；T3=所有猪)也明显减少。未发现与给药有关的不良反应，也未观察到注射部位反应。结论：两种抗菌药物治疗猪急性胸膜肺炎安全有效。在抗生素治疗之间没有检测到统计学上的显著差异。
Background: Porcine pleuropneumonia, caused by Actinobacillus pleuropneumoniae, is a bacterial respiratory disease of swine. Acute outbreaks of the disease are often accompanied by high mortality and economic losses. As severe cases of the disease frequently require parenteral antibiotic treatment of the animals, the efficacy of a single, high dose of marbofloxacin was compared to a three-time application of a dose of enrofloxacin under experimental conditions.Methods: A blinded, controlled, randomized and blocked dose confirmation study was conducted to test the efficacy and safety of a single dose of 8 mg/kg marbofloxacin (160 mg/ml, Forcyl (R) Swine, Vetoquinol SA, France) to treat acute porcine pleuropneumonia after experimental aerosol inoculation of pigs with A. pleuropneumoniae serotype 2. The results were compared to a three consecutive day treatment of 2.5 mg/kg enrofloxacin and a mock (saline) treatment. Criteria for the assessment of efficacy were severity of lung lesions, bacteriological cure and the course of clinical disease after treatment.Results:: Thirty six nursery pigs were divided into three treatment groups: marbofloxacin (T1), enrofloxacin (T2) and mock (T3). Statistically significant superiority (p < 0.05) of marbofloxacin and enrofloxacin compared to the mocktreated group was demonstrated for all efficacy criteria. The need of rescue euthanasia due to severity of symptoms was significantly reduced in both treatment groups (T1: 1 pig; T2: 0 pigs; vs. T3: 8 pigs). On day 6 after treatment initiation, clinical cure was observed in 10 (T1), 10 (T2) but only 1 of the piglets in T3. Extent of lung lesions (mean of lung lesion score T1: 3.9, T2: 6.0, T3: 21.1) and bacteriological isolation from lung tissue (on day 6 after treatment initiation: T1 = 0 pigs; T2 = 1 pig; T3 = all pigs) were also significantly reduced within both treatment groups. There were no adverse events linked to the drug administration and no injection site reactions were observed.Conclusions: Both applied antimicrobial treatments were proven safe and efficacious for the treatment of acute porcine pleuropneumonia. No statistically significant differences were detected between the antibiotic treatments.