Avian retrovirus S13: properties of the genome and of the transformation-specific protein.
Avian retrovirus S13: properties of the genome and of the transformation-specific protein.
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禽逆转录病毒 S13：基因组和转化特异性蛋白的特性。
DOI：
10.1016/0042-6822(85)90210-7
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发表时间：
1985
期刊：
影响因子：
3.7
通讯作者：
Vogt,PK
中科院分区：
文献类型：
--
作者：
Benedict,SH;Maki,Y;Vogt,PK
禽流感逆转录病毒S13编码一种环状病毒连锁的转化特异性糖蛋白，分子量为155,000(Gp155)。用内切糖苷酶H处理gp155或在衣霉素存在下生长S13感染的细胞，使gp155的相对分子质量降低到约140K，但这些gp155相关分子可能仍含有糖残基。Gp155蛋白没有结合到病毒粒子中；它被磷酸化，但在免疫沉淀物中不显示蛋白激酶活性。S13的基因组是一个8.5kb的RNA；辅助病毒基因组的大小为7.5kb。S13的恶变序列不与代表src、erba、erbB、myc、myb、fps、fms、H-ras、B-lym、abl、rel等的DNA探针杂交。
The avian retrovirus S13 codes for anenv-linked transformation-specific glycoprotein with a molecular weight of 155,000 (gp155). Treatment of gp155 with endoglycosidase H or growth of S13-infected cells in the presence of tunicamycin reduces the molecular weight of gp155 to about 140K, but these gp155-related molecules may still contain sugar residues. The gp155 protein is not incorporated into virions; it is phosphorylated, but in immunoprecipitates does not show protein kinase activity. The genome of S13 is an 8.5-kilobase (kb) RNA; the helper virus genome is 7.5 kb in size. The putativeoncsequences of S13 do not hybridize to DNA probes representingsrc, erbA,erbB,myc,myb,fps,fms, H-ras, B-lym,abl,rel, andets.