EFFECT OF HYPERTHYROIDISM ON LIPOGENESIS IN BROWN ADIPOSE-TISSUE OF YOUNG-RATS
EFFECT OF HYPERTHYROIDISM ON LIPOGENESIS IN BROWN ADIPOSE-TISSUE OF YOUNG-RATS
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DOI：
10.1016/0005-2760(83)90284-9
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发表时间：
1983-01-01
期刊：
影响因子：
--
通讯作者：
QUAGLIARIELLO, E
中科院分区：
文献类型：
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作者：
GNONI, GV;LANDRISCINA, C;QUAGLIARIELLO, E
在亚细胞部分和体内研究的脂肪酸合成能力，在室温习服的大鼠的棕色脂肪组织中非常活跃。在甲亢动物中，这一组织类似于肝脏，表现出乙酰辅酶A羧基酶、脂肪酸合成酶和微粒体脂酸链延长的活性增加，最后一种机制在线粒体中保持不受影响。甲亢大鼠棕色脂肪组织中一组胞浆NADP依赖酶的还原能力也增强，这可能是由于在这种条件下NADPH在脂肪生成中的更多使用。观察到甲亢动物棕色脂肪组织线粒体棕榈酸氧化和多烯脂肪酸的增加。后者的增加与这些化合物在调节细胞膜流动性方面的重要性有关，也可能与甲亢状态下对寒冷的抵抗力增强有关。
Fatty acid synthetic capacity, investigated both in subcellular fractions and in vivo, is very active in brown adipose tissue of room temperature-acclimated rats. In hyperthyroid animals this tissue, analogously to the liver, exhibits an increased activity of acetyl-CoA carboxylase, fatty acid synthetase and microsomal fatty acid chain elongation, this last mechanism remaining unaffected in mitochondria. An enhancement of reducing capacities of a group of cytoplasmic NADP-dependent enzymes was also observed in brown adipose tissue of hyperthyroid rats, probably due to a greater use of NADPH in lipogenesis under these conditions. An increase in palmitate oxidation and in polyenoic fatty acids was observed in mitochondria of brown adipose tissue from hyperthyroid animals. The latter increase is related to the importance of these compounds in the regulation of membrane fluidity and probably to an increased resistance to cold in the hyperthyroid state.