Insulin-like growth factor I restores motor coordination in a rat model of cerebellar ataxia
Insulin-like growth factor I restores motor coordination in a rat model of cerebellar ataxia
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DOI：
10.1073/pnas.95.3.1253
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发表时间：
1998-02-03
影响因子：
11.1
通讯作者：
Torres-Aleman, I
中科院分区：
文献类型：
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作者：
Fernandez, AM;de la Vega, AG;Torres-Aleman, I
我们测试了胰岛素样生长因子I （IGF-I）在小脑共济失调动物模型中诱导功能恢复的潜力，因为在人类和啮齿动物中，这种运动损伤伴随着IGF-I营养系统的几个组成部分的明显变化。通过行为和电生理测试确定，由于3-乙酰吡啶导致小脑皮层神经分化丧失而导致共济失调的大鼠在服用IGF-I后恢复了运动功能。当用IGF-I治疗时，作为神经毒素靶点的下橄榄神经元在不同程度上被拯救（存活神经元的92%至27%），这取决于IGF-I治疗开始的时间。此外，即使在严重神经元丢失的大鼠中，无论通过何种途径（脑室内或皮下）给予营养因子，也能获得完全恢复。这些结果表明，IGF-I可以通过简单的程序治疗人类失调。
We tested the potential of insulin-like growth factor I (IGF-I) to induce functional recovery in an animal model of cerebellar ataxia because this motor impairment is accompanied in humans and rodents by distinct changes in several components of the IGF-I trophic system, Rats rendered ataxic by deafferentation of the cerebellar cortex with 3-acetylpyridine recovered motor function after IGF-I was administered, as determined by behavioral and electrophysiological tests. When treated with IGF-I, inferior olive neurons, the targets of the neurotoxin, were rescued to various degrees (from 92 to 27% of surviving neurons), depending on the time that treatment with IGF-I was initiated, Furthermore, full recovery was obtained regardless of the route by which the trophic factor was administered (intraventricular or subcutaneous) even in rats with severe neuronal loss, These results suggest that human ataxia could be treated with IGF-I by a simple procedure.