Nickel-catalyzed decarbonylative addition of phthalimides to alkynes
Nickel-catalyzed decarbonylative addition of phthalimides to alkynes
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DOI：
10.1021/ja7114426
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发表时间：
2008-05-14
影响因子：
15
通讯作者：
Kurahashi, Takuya
中科院分区：
文献类型：
--
作者：
Kajita, Yuichi;Matsubara, Seijiro;Kurahashi, Takuya
已开发出一种分子间镍催化加成反应，其中 N-芳基邻苯二甲酰亚胺与炔烃反应生成取代的异喹诺酮。提出了一个机械原理，暗示 Ni(0) 对酰胺的亲核攻击是催化循环的主要步骤。
An intermolecular nickel-catalyzed addition reaction has been developed where N-arylphthalimides react with alkynes to afford substituted isoquinolones. A mechanistic rationale is proposed, implying nucleophilic attack of Ni(0) to an amide as the primary step of the catalytic cycle.