A formal total synthesis of virantmycin:: A modular approach towards tetrahydroquinoline natural products
A formal total synthesis of virantmycin:: A modular approach towards tetrahydroquinoline natural products
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DOI：
10.1002/ejoc.200600635
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发表时间：
2006-10-27
影响因子：
2.8
通讯作者：
Brase, Stefan
中科院分区：
文献类型：
--
作者：
Keck, Daniel;Vanderheiden, Sylvia;Brase, Stefan
以分子内氮杂亚二甲苯基Diels-Alder反应为特征，开发了一种抗病毒药物病毒霉素外消旋体的高级中间体的合成方法。所需的芳基硫代氨基甲酸酯已被构建使用一个有效的氧化环化策略。报道了一种新的合成氯取代烯丙醇的方法，该方法使用前所未有的钯催化的α，β-不饱和酮和保护的炔丙醇的交叉偶联反应。((c)Wiley-VCH Verlag GmbH & Co. KGaA，69451魏因海姆，德国，2006）。
A synthesis of an advanced intermediate towards the racemic form of the antiviral agent virantmycin has been developed featuring an intramolecular aza-xylylene Diels-Alder reaction. The required arylthiocarbamate has been constructed using an efficient oxidative cyclization strategy. A novel synthetic approach to chlorine-substituted allylic alcohols using an unprecedented palladium-catalyzed cross-coupling reaction of alpha,beta-unsaturated ketones and protected propargylic alcohols is reported. ((c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006).