Multidimensional crosstalk between RNA-binding proteins and noncoding RNAs in cancer biology
Multidimensional crosstalk between RNA-binding proteins and noncoding RNAs in cancer biology
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癌症生物学中 RNA 结合蛋白和非编码 RNA 之间的多维串扰
DOI：
10.1016/j.semcancer.2021.03.007
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发表时间：
2021-11-22
影响因子：
14.5
通讯作者：
Song, Xu
中科院分区：
文献类型：
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作者：
Li, Ling;Miao, Hui;Song, Xu
众所周知，RNA结合蛋白（RBP）通过一组RNA结合结构域（RBD）结合RNA，并决定其RNA靶标的命运和功能;相反，在某些情况下，一些RBP可能受结合RNA的调节，而不是调节其RNA伴侣。目前的蛋白质组研究表明，近一半的RBP没有典型的RBD，而数以万计的非编码RNA（ncRNA）的发现，特别是那些长度大于200 nt的长链非编码RNA（longnoncodingRNAs，lncRNA）的发现，使得RBP与RNA之间的相互作用变得更加复杂。RBP与RNA形成的大分子复合物不仅是RBP和RNA组分在细胞中的一种存在形式，而且是RBP和调控ncRNA参与构建生物体调控网络的功能实体。本文综述了RBP与ncRNA在肿瘤中的多维相互作用，并讨论了RBP如何通过结合ncRNA在基因表达的不同方面发挥作用，以及RBP如何指导ncRNA的修饰和加工，以期更好地理解肿瘤生物学，并为癌症治疗和早期检测策略的发展提供新的见解。
RNA-binding proteins (RBPs) are well-known to bind RNA via a set of RNA-binding domains (RBDs) and determine the fate and function of their RNA targets; inversely, some RBPs, in certain cases, may be modulated by the bound RNAs rather than regulate their RNA partners. Current proteome-wide studies reveal that almost half of RBPs have no canonical RBDs, and the discovery of tens of thousands of noncoding RNAs (ncRNAs), especially those with the size larger than 200 nt (namely long noncoding RNAs, lncRNAs), makes the crosstalk between RBPs and RNAs more complicated. It is clear that macromolecular complexes formed by RBP and RNA are not only a form of existence of their RBP and RNA components in cells, but also represent a functional entity through which those RBPs and regulatory ncRNAs participate in the construction of regulatory networks in organism. In this review, we summarize the multidimensional crosstalk between RBPs and ncRNAs in cancer and discuss how RBPs achieve their function via the bound ncRNAs in different aspects of gene expression as well as how RBPs direct modification and processing of ncRNAs, in order to better understand tumor biology and provide new insights into development of strategies for cancer therapy and early detection.