Synthesis and mitochondrial complex I inhibition of dihydroxy-cohibin A, non-THF annonaceous acetogenin analogue
Synthesis and mitochondrial complex I inhibition of dihydroxy-cohibin A, non-THF annonaceous acetogenin analogue
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DOI：
10.1016/j.bmcl.2003.11.057
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发表时间：
2004-02-09
影响因子：
2.7
通讯作者：
Miyoshi, H
中科院分区：
文献类型：
--
作者：
Konno, H;Hiura, N;Miyoshi, H
为了阐明 acetogenin 的抑制作用，我们合成了一种用四醇代替四氢呋喃环的 acetogenin 衍生物，并检测了其对牛心脏线粒体复合物 I 的抑制活性。我们的结果表明，这些羟基是一个重要的结构因子，尽管它不像双 THF 羟基组合那样有效。 (C) 2003 Elsevier Ltd. 保留所有权利。
To elucidate the inhibitory action of acetogenins, we synthesized an acetogenin derivative which possesses tetraol in place of the tetrahydrofuran ring and examined its inhibitory activity against bovine heart mitochondrial complex I. Our results indicate that these hydroxy groups are an essential structural factor though it is not effective as bis-THF hydroxy groups combination. (C) 2003 Elsevier Ltd. All rights reserved.