A Low Power Light Weight Wireless Multichannel Microsystem for Reliable Neural Recording
A Low Power Light Weight Wireless Multichannel Microsystem for Reliable Neural Recording
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DOI：
10.1109/jssc.2013.2293773
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发表时间：
2014-02-01
影响因子：
5.4
通讯作者：
Najafi, Khalil
中科院分区：
文献类型：
--
作者：
Borna, Amir;Najafi, Khalil
本文报道了一种可靠、单芯片、多通道无线生物遥测微系统的设计和开发，该系统旨在用于从清醒和行为小动物模型中进行细胞外神经记录。确定了可靠神经记录的系统要求，并在架构和电路级别解决了低功耗和可靠性的固有冲突要求。 2.85 X 3.84 mm(2) 混合信号 ASIC 采用 0.5 μm 2P3M n 井标准 CMOS 工艺制造；并在单芯片上集成了低噪声前端、可编程数字控制器、射频调制器和 433 MHz ISM 频段的射频功率放大器。该微系统采用 ASIC，具有 9 通道，可编程，重量为 2.2 g（包括电池），尺寸为 2.2 X 1.1 X 0.5 cm(3)。该发射器功耗为 5 mW，在传输距离为 3 m、10 m 和 20 m 时测得的输入参考电压噪声分别为 4.58 mu V-rms、6.20 mu V-rms 和 7.81 mu V-rms。实测通道间串扰小于3.5%，电池续航时间约为1小时。所提出的生物遥测系统已成功用于两个体内神经记录实验：i）来自自由漫游的南美蟑螂的天线，ii）来自清醒且活动的老鼠的海马体。
This paper reports on design and development of a reliable, single-chip, multichannel wireless biotelemetry microsystem intended for extracellular neural recording from awake, and behaving small animal models. The system requirements for reliable neural recording are identified and the inherently conflicting requirements of low power and reliability are addressed at architectural and circuit levels. The 2.85 X 3.84 mm(2), mixed-signal ASIC is fabricated in a 0.5 mu m 2P3M n-well standard CMOS process; and integrates a low-noise front-end, programmable digital controller, an RF modulator, and an RF power amplifier at the ISM band of 433 MHz on a single-chip. The microsystem, incorporating the ASIC, features 9-channel, is programmable, weighs 2.2 g (including batteries) and has dimensions of 2.2 X 1.1 X 0.5 cm(3). The transmitter consumes 5 mW and has a measured input referred voltage noise of 4.58 mu V-rms, 6.20 mu V-rms, and 7.81 mu V-rms at transmission distances of 3 m, 10 m, and 20 m, respectively. The measured inter-channel crosstalk is less than 3.5% and battery life is about an hour. The presented biotelemetry system has been successfully used in two in-vivo neural recording experiments: i) from the antennas of a freely roaming South-American cockroach, and ii) from the hippocampus of an awake and mobile rat.